{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T14:13:46Z","timestamp":1783779226040,"version":"3.55.0"},"reference-count":35,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:00:00Z","timestamp":1783468800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Laparoendoscopic &amp; Advanced Surgical Techniques"],"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Severe obesity is a growing global health issue and a significant risk factor for cardiovascular diseases. Bariatric and metabolic surgeries, such as sleeve gastrectomy (SG) and Roux-en-Y gastric bypass (RYGB), are effective interventions for managing cardiometabolic comorbidities associated with obesity. This study investigates early changes in leptin and perilipin-1 levels following SG and RYGB and their impact on cardiometabolic comorbidities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      A total of 60 individuals with severe obesity (body mass index [BMI] &gt;35 kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      with cardiometabolic comorbidities or BMI &gt;40 kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ) underwent bariatric and metabolic surgery at a single center. Demographic data, preoperative and postoperative (1st-month) laboratory values (leptin, perilipin-1, hemoglobin A1c [HbA1c], low-density lipoprotein [LDL] cholesterol, triglycerides), and weight loss were recorded. Statistical analyses compared changes between the groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Forty individuals underwent SG, and 20 underwent RYGB. Both SG and RYGB resulted in significant weight loss and improvements in metabolic parameters within the first 30 postoperative days. Perilipin-1, a lipid droplet-coating protein that regulates lipolysis and is implicated in atherosclerotic plaque formation, showed significantly different postoperative trajectories between the two groups. RYGB demonstrated greater reductions in leptin and perilipin-1 levels compared with SG (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .007 for perilipin-1). LDL cholesterol and HbA1c levels also decreased more significantly in the RYGB group. While SG showed no significant changes in perilipin-1 levels postoperatively, RYGB significantly reduced this marker, suggesting superior efficacy in addressing obesity-related cardiometabolic comorbidities.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Within the first 30 postoperative days, RYGB produces earlier and more pronounced reductions in key metabolic markers, including leptin, perilipin-1, LDL cholesterol, and HbA1c, compared with SG. These early hormonal differences may help explain the long-term cardiometabolic advantages of RYGB reported in the literature and support prioritizing RYGB in patients with severe obesity with associated metabolic comorbidity components. Further prospective studies with long-term follow-up are warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10926429261468941","type":"journal-article","created":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T05:42:23Z","timestamp":1783575743000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["In Obesity Patients, Is the Goal to Lose Weight or to Fight Metabolic Syndrome Components? How Did Leptin and Perilipin 1 Guide US in the Choice of Surgical Procedure?"],"prefix":"10.1177","author":[{"given":"Orhan","family":"Aras","sequence":"first","affiliation":[{"name":"Gastroenterology Surgery Department, Antalya Training and Research Hospital, Antalya, Turkey."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u0131dvan","family":"Yavuz","sequence":"additional","affiliation":[{"name":"Gastroenterology Surgery Department, Antalya Training and Research Hospital, Antalya, Turkey."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zinet Asuman","family":"Onuk","sequence":"additional","affiliation":[{"name":"Anesthesiology and Reanimation Department, Antalya Training and Research Hospital, Antalya, Turkey."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00fcseyin","family":"\u00c7iyiltepe","sequence":"additional","affiliation":[{"name":"Gastroenterology Surgery Department, Antalya Training and Research Hospital, Antalya, Turkey."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sibel","family":"Kulaks\u0131zo\u011flu","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Antalya Training and Research Hospital, Antalya, Turkey."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tebess\u00fcm","family":"\u00c7ak\u0131r","sequence":"additional","affiliation":[{"name":"Gastroenterology Surgery Department, Antalya Training and Research Hospital, Antalya, Turkey."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Halit","family":"\u00d6zg\u00fcl","sequence":"additional","affiliation":[{"name":"General Surgery Department, Antalya Training and Research Hospital, Antalya, Turkey."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6mer","family":"K\u00fcrkl\u00fc","sequence":"additional","affiliation":[{"name":"Gastroenterology Surgery Department, Antalya Training and Research Hospital, Antalya, Turkey."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,7,8]]},"reference":[{"key":"e_1_3_2_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67483-1"},{"key":"e_1_3_2_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05487"},{"key":"e_1_3_2_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2009.07.019"},{"issue":"1","key":"e_1_3_2_5_1","first-page":"H13","article-title":"Adiponectin, leptin, and obesity-related vascular dysfunction","volume":"296","author":"Steinberg GR","year":"2009","unstructured":"4.Steinberg GR, , Schertzer JD. 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Relation of increased leptin concentrations to history of myocardial infarction and stroke. Am J Cardiol 2007;100(2):234\u2013239.","journal-title":"Am J Cardiol"},{"key":"e_1_3_2_26_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa035622"},{"key":"e_1_3_2_27_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1600869"},{"key":"e_1_3_2_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5273(02)00480-1"},{"key":"e_1_3_2_29_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.22.1.65"},{"key":"e_1_3_2_30_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0123738"},{"key":"e_1_3_2_31_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgac104"},{"key":"e_1_3_2_32_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2017-02662"},{"key":"e_1_3_2_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1098-3597(08)60025-3"},{"key":"e_1_3_2_34_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M013599"},{"issue":"1","key":"e_1_3_2_35_1","first-page":"25","article-title":"LDL cholesterol and atherosclerosis: The evidence","volume":"33","author":"Guijarro C","year":"2021","unstructured":"34.Guijarro C, , Sales JC. 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