{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T18:35:56Z","timestamp":1777660556891,"version":"3.51.4"},"reference-count":15,"publisher":"SAGE Publications","issue":"1-2","license":[{"start":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T00:00:00Z","timestamp":1739318400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Human Antibodies"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Anti-inflammatory cytokines is thought to influence the onset and course of chronic kidney disease (CKD). Particular cytokines include Interleukin-10 (IL-10), which is usually considered anti-inflammatory.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The current study designed to determine the activity of the IL10 and their roles in chronic kidney disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This research is done, forty- five blood samples were collected from patients with chronic kidney disease and 42 volunteers. A sandwich ELISA was used to estimate the serum levels of human Interleukin-10.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The mean age among patient groups (males, females) it was 47.40\u2009\u00b1\u20092.96 and 62.64\u2009\u00b1\u200914.46 years, respectively. While the control groups (males, females) were 40.97\u2009\u00b1\u20091.67 and 45.25\u2009\u00b1\u20097.13 years (p\u2009&gt;\u20090.05). Of the 45 patients, 20 (44.4%) were males, 25 (55.6%) females. The resulted data showed that there are no significant (p\u2009&gt;\u20090.05) for the total of the mean of human IL-10 between patients and control, respectively, where the mean level of IL10 in males was 190.10\u2009\u00b1\u200915.07&amp; 154.18\u2009\u00b1\u20098.77 (p\u2009&lt;\u20090.05) respectively and 142.22\u2009\u00b1\u200912.43 &amp; 117.04\u2009\u00b1\u200914.66 in females, but not significantly (p\u2009&gt;\u20090.05), and revealed an highly increased significant in this marker during the course of the chronic kidney disease in males more than females in patients (p\u2009&lt;\u20090.05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Can conclude from this study that decreased anti-inflammatory cytokine IL10 likely affects CKD progression and prognosis in females specifically.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10932607251317417","type":"journal-article","created":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T05:35:02Z","timestamp":1739338502000},"page":"48-51","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Role of anti-inflammatory cytokine (IL10) in patients with chronic kidney disease"],"prefix":"10.1177","volume":"33","author":[{"given":"Duaa Mohammed","family":"Abdulsatar","sequence":"first","affiliation":[{"name":"Department of Microbiology, College of Medicine, AL-Iraqia University, Baghdad, Iraq"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hayfaa Mahmood","family":"Fahad","sequence":"additional","affiliation":[{"name":"Department of Microbiology, College of Medicine, AL-Iraqia University, Baghdad, Iraq"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6202-0109","authenticated-orcid":false,"given":"Sahar Taha","family":"Hatif","sequence":"additional","affiliation":[{"name":"Department of Microbiology, College of Medicine, AL-Iraqia University, Baghdad, Iraq"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-2627-9358","authenticated-orcid":false,"given":"Zaid Jaafar","family":"Awad Al-Nuaimi","sequence":"additional","affiliation":[{"name":"College of Dentistry, AL-Iraqia University, Baghdad, Iraq"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,2,12]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)00519-5"},{"issue":"1","key":"e_1_3_4_3_2","first-page":"20","article-title":"Kidney disease: chronic kidney disease","volume":"509","author":"Braun MM","year":"2021","unstructured":"Braun MM, Khayat M. Kidney disease: chronic kidney disease. FP Essent 2021; 509(Suppl 1): 20\u201325.","journal-title":"FP Essent"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2018.12.044"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23020647"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2010.09.002"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2022.108917"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.14541"},{"key":"e_1_3_4_9_2","volume-title":"IBM SPSS statistics for windows (version 25.0 Armonk)","author":"I. B. M. Corportation","year":"2017","unstructured":"I. B. M. Corportation. IBM SPSS statistics for windows (version 25.0 Armonk). 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Medico-Legal Updat 2020; 20: 1446\u20131451.","journal-title":"Medico-Legal Updat"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(03)00353-6"}],"container-title":["Human Antibodies"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10932607251317417","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10932607251317417","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10932607251317417","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T07:22:50Z","timestamp":1777447370000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10932607251317417"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,12]]},"references-count":15,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["10.1177\/10932607251317417"],"URL":"https:\/\/doi.org\/10.1177\/10932607251317417","relation":{},"ISSN":["1093-2607","1875-869X"],"issn-type":[{"value":"1093-2607","type":"print"},{"value":"1875-869X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,12]]}}}