{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T12:53:57Z","timestamp":1792155237236,"version":"4.4.0"},"reference-count":35,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Human Antibodies"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Pediatric asthma is a respiratory disease involving bronchial hyperresponsiveness to risk factors, influenced by genetic and environmental factors.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Objective:<\/jats:bold>\n                      This study investigated IL-38\/IL-36R in pediatric asthma. Samples from 140 children aged 1\u201310 years, including 80 patients and 60 controls, were analyzed. IL-38 mRNA expression was assessed by qRT-PCR, while serum IL-38 and IL-36R were measured by ELISA.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Revealed significant increase serum level of IL-38 74.80\u00b1 11.583pg\/ml in asthmatic patients compare to control 59.33\u00b1 11.833pg\/ml (P=0.01) while serum level of IL-36R in patients 226.26 \u00b188.07 pg\/ml compare to control group167.4250 \u00b155.03pg\/ml, results of expression of mRNA level of IL-38 shows significantly increased in asthmatic patients 2 fold with p value &lt;0.01, significant correlation between serum level of IL-38 and IL-36R (r= \u22120.7459, p value =0.001), while weak correlation between concentration of IL-36R and mRNA expression of IL-38.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The results showed that the changes in serum and expression levels of IL-38 have significant impact on asthma disease and its severity. These levels may account as diagnostic marker for pediatric asthma.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10932607261495881","type":"journal-article","created":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T15:44:31Z","timestamp":1791992671000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Protein and mRNA expression level of IL-38 and correlation with IL-36R in pediatric asthmatic patients"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4952-8087","authenticated-orcid":false,"given":"Basima Q.","family":"Alsaadi","sequence":"first","affiliation":[{"name":"University of Baghdad"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6837-8905","authenticated-orcid":false,"given":"Mayada H.","family":"Ali","sequence":"additional","affiliation":[{"name":"University of Baghdad"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-4157-712X","authenticated-orcid":false,"given":"Fatima H.","family":"Abbas","sequence":"additional","affiliation":[{"name":"University of Baghdad"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-4261-3513","authenticated-orcid":false,"given":"Duaa F.","family":"Al-Mashhadani","sequence":"additional","affiliation":[{"name":"Blood Bank Unit, Al-Yarmouk Teaching Hospital, Ministry of Health","place":["Iraq"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,10,14]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules21070933"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.21608\/ejpa.2016.16761"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/s43168-022-00139-5"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/all.14425"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2018.00186"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-019-0300-7"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/iid3.991"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.2001.01602.x"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1684\/ecn.2022.0480"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacig.2025.100419"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13223-023-00834-y"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13223-023-00868-2"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.2147\/JAA.S522950"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.24996\/ijs.2020.61.12.8"},{"key":"e_1_3_3_16_2","article-title":"Impact of IL-4R (rs1805011) gene polymorphism on IL-4 serum level in Iraqi allergic asthma patients","volume":"21","author":"AL-Qadhi IY","year":"2022","unstructured":"AL-Qadhi IY, AL-Saadi BQ. 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