{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T23:29:53Z","timestamp":1777937393308,"version":"3.51.4"},"reference-count":16,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2017,1,25]],"date-time":"2017-01-25T00:00:00Z","timestamp":1485302400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Pediatr Dev Pathol"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:p>Vitamin B12 deficiency is a known cause of megaloblastic anemia and bone marrow failure. Bone marrow biopsies are not frequently performed as part of the diagnostic workup and can demonstrate morphologic features that overlap with myelodysplastic syndrome (MDS) and acute leukemia. We describe a case of a dysplastic bone marrow with increased bone marrow hematogones detected by flow cytometry in a child with vitamin B12 deficiency. Hematogones are normal B cell precursors, and hyperplasia has been described in a variety of often reactive conditions and also disease. Hematogones are not typically seen in MDS. The presence of hematogones may help differentiate the dysplastic changes seen in vitamin B12 deficiency from MDS.<\/jats:p>","DOI":"10.1177\/1093526616686241","type":"journal-article","created":{"date-parts":[[2017,7,18]],"date-time":"2017-07-18T10:13:22Z","timestamp":1500372802000},"page":"172-175","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Hematogones Detected by Flow Cytometry in a Child with Vitamin B12 Deficiency"],"prefix":"10.1177","volume":"20","author":[{"given":"Lisa","family":"Sutton","sequence":"first","affiliation":[{"name":"Department of Pathology, Driscoll Children\u2019s Hospital, Corpus Christi, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nkechi","family":"Mba","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology, Driscoll Children\u2019s Hospital, Corpus Christi, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,1,25]]},"reference":[{"key":"bibr1-1093526616686241","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1113996"},{"key":"bibr2-1093526616686241","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-6196(12)61046-5"},{"key":"bibr3-1093526616686241","doi-asserted-by":"crossref","unstructured":"Randhawa J, Ondrejka SL, Setrakian S, Taylor H. What should I know before ordering a bone marrow aspiration\/biopsy in patients with vitamin B12 deficiency?\n                      BMJ Case Rep\n                      . Published online 8 July 2013. doi: 10.1136\/bcr-2013-010200.","DOI":"10.1136\/bcr-2013-010200"},{"key":"bibr4-1093526616686241","doi-asserted-by":"crossref","unstructured":"Wilson CS, Brynes RK (2011). Evaluation of anemia, leukopenia, and thrombocytopenia. In: ES Jaffe, NL Harris, JW Vardiman, E Campo, D Arber (Eds.).\n                      Hematopathology\n                      1st ed. St. Louis, MI: Saunders, 2011.","DOI":"10.1016\/B978-0-7216-0040-6.00011-3"},{"key":"bibr5-1093526616686241","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V98.8.2498"},{"key":"bibr6-1093526616686241","doi-asserted-by":"publisher","DOI":"10.1309\/4W2G3NDXUPG5J33N"},{"key":"bibr7-1093526616686241","doi-asserted-by":"publisher","DOI":"10.3109\/10428190903370346"},{"key":"bibr8-1093526616686241","doi-asserted-by":"publisher","DOI":"10.1309\/AJCPS3ENUQ5LKBSB"},{"key":"bibr9-1093526616686241","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2014.107706"},{"key":"bibr10-1093526616686241","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2009.005801"},{"key":"bibr11-1093526616686241","doi-asserted-by":"publisher","DOI":"10.4172\/2165-7920.1000430"},{"key":"bibr12-1093526616686241","doi-asserted-by":"publisher","DOI":"10.1159\/000322941"},{"key":"bibr13-1093526616686241","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-199605000-00013"},{"key":"bibr14-1093526616686241","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-012-1488-0"},{"key":"bibr15-1093526616686241","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-199605000-00014"},{"key":"bibr16-1093526616686241","doi-asserted-by":"publisher","DOI":"10.1007\/s002770000272"}],"container-title":["Pediatric and Developmental Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1093526616686241","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1093526616686241","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1093526616686241","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T04:03:11Z","timestamp":1777694591000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1093526616686241"}},"subtitle":["A Case Report"],"short-title":[],"issued":{"date-parts":[[2017,1,25]]},"references-count":16,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["10.1177\/1093526616686241"],"URL":"https:\/\/doi.org\/10.1177\/1093526616686241","relation":{},"ISSN":["1093-5266","1615-5742"],"issn-type":[{"value":"1093-5266","type":"print"},{"value":"1615-5742","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,25]]}}}