{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T23:30:00Z","timestamp":1777937400957,"version":"3.51.4"},"reference-count":49,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2017,2,10]],"date-time":"2017-02-10T00:00:00Z","timestamp":1486684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Pediatr Dev Pathol"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:p>Deregulation of MYC oncoprotein in cancers can result from multiple oncogenic mechanisms. Although MYC translocations define Burkitt lymphoma and MYC protein expression is a poor prognostic factor in undifferentiated neuroblastomas, the distribution of MYC protein (c-MYC) across other pediatric small round blue cell tumors (SRBCT) has not been well characterized. We undertook this study to assess MYC protein expression in a large cohort of pediatric lymphomas, sarcomas, and other SRBCT. Tissue microarrays containing 302 SRBCT were successfully evaluated by immunohistochemistry using anti-MYC clone Y69, with nuclear positivity scored as 0%, 1%\u201325%, 26%\u201350%, 51%\u201375%, or 76%\u2013100%. MYC protein staining of &gt;50% of lesional cells was identified in 60% of Burkitt lymphomas, 50% of B lymphoblastic lymphomas, 33% of T lymphoblastic lymphomas, 31% of rhabdomyosarcomas, 33% of Ewing sarcomas, and 25% of soft tissue sarcomas, not otherwise specified. Only 14% of neuroblastomas showed &gt;50% staining, and of these, if known, MYCN was not amplified. No cases of Wilms tumor, synovial sarcoma, or desmoplastic small round cell tumor had &gt;50% staining. Recurrences and metastases often had the same percentage of MYC staining (15\/30). In conclusion, MYC protein exhibited variable expression across and within pediatric SRBCT subtypes. Overall, these findings provide a baseline for MYC expression in pediatric SRBCT and suggest that there may be multiple mechanisms of MYC upregulation in these different neoplasms.<\/jats:p>","DOI":"10.1177\/1093526616689642","type":"journal-article","created":{"date-parts":[[2017,7,20]],"date-time":"2017-07-20T01:13:49Z","timestamp":1500513229000},"page":"213-223","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["Immunohistochemical Profile of MYC Protein in Pediatric Small Round Blue Cell Tumors"],"prefix":"10.1177","volume":"20","author":[{"given":"Karen M","family":"Chisholm","sequence":"first","affiliation":[{"name":"Department of Pathology, Stanford University School of Medicine, Stanford, California, USA"},{"name":"Now at Seattle Children\u2019s Hospital, Department of Laboratories, Seattle, Washington, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chandra","family":"Krishnan","sequence":"additional","affiliation":[{"name":"Dell Children\u2019s Medical Center, Department of Pathology, Austin, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy","family":"Heerema-McKenney","sequence":"additional","affiliation":[{"name":"Pathology and Laboratory Medicine Institute, Cleveland Clinic Cleveland, Ohio, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasodha","family":"Natkunam","sequence":"additional","affiliation":[{"name":"Department of Pathology, Stanford University School of Medicine, Stanford, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,2,10]]},"reference":[{"key":"bibr1-1093526616689642","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2006.07.014"},{"key":"bibr2-1093526616689642","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcmd.2010.08.002"},{"key":"bibr3-1093526616689642","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagrm.2014.04.004"},{"key":"bibr4-1093526616689642","doi-asserted-by":"publisher","DOI":"10.1038\/nrc904"},{"key":"bibr5-1093526616689642","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2231"},{"key":"bibr6-1093526616689642","unstructured":"Howlader N, Noone AM, Krapcho M, et\u00a0al.\n                      SEER Cancer Statistics Review, 1975\u20132013\n                      . 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Lyon, France: IARC Press; 2013."},{"key":"bibr21-1093526616689642","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181b0ebdc"},{"key":"bibr22-1093526616689642","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000365"},{"key":"bibr23-1093526616689642","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2401244"},{"key":"bibr24-1093526616689642","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2014.06.022"},{"key":"bibr25-1093526616689642","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-02-336842"},{"key":"bibr26-1093526616689642","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3665"},{"key":"bibr27-1093526616689642","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2009.64"},{"key":"bibr28-1093526616689642","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1450406"},{"key":"bibr29-1093526616689642","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199904010-00015"},{"key":"bibr30-1093526616689642","first-page":"321","volume":"59","author":"Tsuda H","year":"1988","journal-title":"Lab Invest"},{"key":"bibr31-1093526616689642","doi-asserted-by":"publisher","DOI":"10.1309\/AJCPA1WN7ARPCMKQ"},{"key":"bibr32-1093526616689642","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24532"},{"key":"bibr33-1093526616689642","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.14.5.3230"},{"key":"bibr34-1093526616689642","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1204437"},{"key":"bibr35-1093526616689642","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.1512"},{"key":"bibr36-1093526616689642","doi-asserted-by":"publisher","DOI":"10.1177\/030089169908500304"},{"key":"bibr37-1093526616689642","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2015.188"},{"key":"bibr38-1093526616689642","first-page":"1876","volume":"63","author":"Saito-Ohara F","year":"2003","journal-title":"Cancer Res"},{"key":"bibr39-1093526616689642","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1208215109"},{"key":"bibr40-1093526616689642","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1520175"},{"key":"bibr41-1093526616689642","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1480523"},{"key":"bibr42-1093526616689642","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1206597"},{"key":"bibr43-1093526616689642","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms10013"},{"key":"bibr44-1093526616689642","doi-asserted-by":"crossref","unstructured":"Alexandrescu S, Akhavanfard S, Harris MH, et\u00a0al. Clinical, pathologic, and genetic features of Wilms tumors with WTX gene mutation.\n                      Pediatr Dev Pathol\n                      . Epub ahead of print 4 Jan 2016. 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