{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T23:30:31Z","timestamp":1777937431888,"version":"3.51.4"},"reference-count":14,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2017,3,14]],"date-time":"2017-03-14T00:00:00Z","timestamp":1489449600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Pediatr Dev Pathol"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:p>Crigler\u2013Najjar syndrome is a hereditary unconjugated hyperbilirubinemia. Two forms of the disease are recognized. Type I is more severe and results in kernicterus if left untreated, and Type II is less severe and responds to phenobarbital. While Crigler\u2013Najjar syndrome is thought by many to have normal liver histology, few reports of the liver pathology exist. Herein, we present a 19-year-old patient with Crigler\u2013Najjar who underwent liver transplantation. The liver showed marked canalicular cholestasis with portal and variable, delicate, bridging fibrosis. Correlation of the patient\u2019s genetic test results and clinical phenotype is presented.<\/jats:p>","DOI":"10.1177\/1093526617697059","type":"journal-article","created":{"date-parts":[[2017,12,14]],"date-time":"2017-12-14T02:26:28Z","timestamp":1513218388000},"page":"522-525","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Liver Fibrosis Associated With Crigler\u2013Najjar Syndrome in a Compound Heterozygote: A Case Report"],"prefix":"10.1177","volume":"20","author":[{"given":"Cynthia R","family":"Fata","sequence":"first","affiliation":[{"name":"Department of Pathology, Microbiology & Immunology, Vanderbilt University Medical Center, Nashville, Tennessee"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lynette A","family":"Gillis","sequence":"additional","affiliation":[{"name":"Monroe Carell Jr. Children\u2019s Hospital at Vanderbilt, D. Brent Polk Division of Gastroenterology, Hepatology, and Nutrition, Nashville, Tennessee"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M Cristina","family":"Pacheco","sequence":"additional","affiliation":[{"name":"Department of Pathology, Microbiology & Immunology, Vanderbilt University Medical Center, Nashville, Tennessee"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,3,14]]},"reference":[{"issue":"2","key":"bibr1-1093526617697059","first-page":"169","volume":"10","author":"Crigler JF","year":"1952","journal-title":"Pediatrics"},{"key":"bibr2-1093526617697059","doi-asserted-by":"publisher","DOI":"10.1126\/science.126.3273.563"},{"key":"bibr3-1093526617697059","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(69)90224-1"},{"key":"bibr4-1093526617697059","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.13071"},{"key":"bibr5-1093526617697059","doi-asserted-by":"publisher","DOI":"10.1007\/BF02125800"},{"key":"bibr6-1093526617697059","doi-asserted-by":"publisher","DOI":"10.1016\/0098-2997(87)90009-4"},{"key":"bibr7-1093526617697059","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejhg.5201989"},{"key":"bibr8-1093526617697059","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcmd.2013.01.003"},{"issue":"1","key":"bibr9-1093526617697059","first-page":"41","volume":"91","author":"Barth RF","year":"1971","journal-title":"Arch Pathol"},{"key":"bibr10-1093526617697059","unstructured":"Emory Genetics Laboratory. http:\/\/geneticslab.emory.edu\/tests\/MM340. 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