{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T11:36:44Z","timestamp":1784547404806,"version":"3.55.0"},"reference-count":17,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2017,3,20]],"date-time":"2017-03-20T00:00:00Z","timestamp":1489968000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Pediatr Dev Pathol"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:p>\n                    Pediatric chronic myelogenous leukemia is uncommon. We report a pediatric patient with chronic myelogenous leukemia presenting with a normal white blood cell count and no circulating immature myeloid cells. The patient presented with extreme thrombocytosis (platelet count range: 2175\u20133064\u2009\u00d7\u200910\n                    <jats:sup>9<\/jats:sup>\n                    \/L) noted incidentally. No splenomegaly was found. Examination of the bone marrow aspirate revealed normal cellularity and normal myeloid: erythroid ratio with marked megakaryocytic hyperplasia. Molecular studies on the bone marrow aspirate detected both the major BCR\/ABL1 p210 fusion transcript (9280 copies; p210\/ ABL1 ratio: 38.2%) and the minor p190 transcript (below limit of quantitation). The platelet count normalized within 2 weeks after treatment with the second-generation tyrosine kinase inhibitor dasatinib. Follow-up after 3 months revealed a 1.87 log reduction in p210 transcripts compared to diagnosis and no detectable p190 transcripts. This case highlights the need to include BCR\/ABL1 fusion testing to accurately diagnose pediatric patients presenting with isolated thrombocytosis.\n                  <\/jats:p>","DOI":"10.1177\/1093526617698601","type":"journal-article","created":{"date-parts":[[2017,11,30]],"date-time":"2017-11-30T01:44:30Z","timestamp":1512006270000},"page":"100-104","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["A Rare Case of Pediatric Chronic Myelogenous Leukemia Presenting With Severe Thrombocytosis Without Leukocytosis"],"prefix":"10.1177","volume":"21","author":[{"given":"Albert N","family":"Huho","sequence":"first","affiliation":[{"name":"Department of Pathology & Immunology, Baylor College of Medicine and Texas Children\u2019s Hospital, Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niveen","family":"Issaq","sequence":"additional","affiliation":[{"name":"Department of Pathology & Immunology, Baylor College of Medicine and Texas Children\u2019s Hospital, Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ionela","family":"Iacobas","sequence":"additional","affiliation":[{"name":"Texas Children's Cancer and Hematology Center, Texas Children's Hospital, Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarek M","family":"Elghetany","sequence":"additional","affiliation":[{"name":"Department of Pathology & Immunology, Baylor College of Medicine and Texas Children\u2019s Hospital, Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dolores","family":"L\u00f3pez-Terrada","sequence":"additional","affiliation":[{"name":"Department of Pathology & Immunology, Baylor College of Medicine and Texas Children\u2019s Hospital, Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin E","family":"Fisher","sequence":"additional","affiliation":[{"name":"Department of Pathology & Immunology, Baylor College of Medicine and Texas Children\u2019s Hospital, Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jyotinder N","family":"Punia","sequence":"additional","affiliation":[{"name":"Department of Pathology & Immunology, Baylor College of Medicine and Texas Children\u2019s Hospital, Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2017,3,20]]},"reference":[{"key":"bibr1-1093526617698601","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2015.09.008"},{"key":"bibr2-1093526617698601","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-06-648667"},{"key":"bibr3-1093526617698601","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004-2473"},{"key":"bibr4-1093526617698601","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.21989"},{"key":"bibr5-1093526617698601","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1998.00945.x"},{"key":"bibr6-1093526617698601","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-012-0348-z"},{"key":"bibr7-1093526617698601","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2257.2002.00413.x"},{"key":"bibr8-1093526617698601","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-4608(97)00263-X"},{"key":"bibr9-1093526617698601","first-page":"669","volume":"45","author":"Mantadakis 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