{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T08:29:56Z","timestamp":1781598596728,"version":"3.54.5"},"reference-count":24,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2017,11,6]],"date-time":"2017-11-06T00:00:00Z","timestamp":1509926400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Pediatr Dev Pathol"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:p>Therapeutic hypothermia (head or whole-body cooling) improves survival and neurodevelopmental outcome in term newborns with moderate-to-severe encephalopathy. Hypothermia treatment is well tolerated; the most common side effect is thrombocytopenia. In about 1% of infants, focal subcutaneous fat necrosis has been reported. We describe a case of clinically unsuspected massive visceral fat necrosis in a term infant with Apgar score 0 at 1\u2009min (\u201cresuscitated apparently stillborn\u201d infant) who was treated with therapeutic hypothermia for 72\u2009h and expired on the 25th day of life following a neonatal course complicated by severe encephalopathy, pulmonary artery hypertension, persistent thrombocytopenia, hypoglycemia, and severe basal ganglia-thalamic abnormalities on magnetic resonance imaging. Postmortem examination revealed extensive visceral (brown) fat necrosis, involving thoracic, abdominal, and retroperitoneal adipose tissue, with distinctive sparing of the subcutaneous (white) fat. The fulminant\u2014yet clinically occult\u2014visceral fat necrosis seen in this case suggests that (lesser degrees of) fat necrosis may go unrecognized in hypoxic-ischemic newborns, especially in those treated with hypothermia, and underscores the importance of close monitoring of encephalopathic newborns both in the short and long terms for complications of fat necrosis (hypercalcemia and nephrocalcinosis).<\/jats:p>","DOI":"10.1177\/1093526617737881","type":"journal-article","created":{"date-parts":[[2017,11,6]],"date-time":"2017-11-06T23:37:06Z","timestamp":1510011426000},"page":"502-506","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Occult Massive Visceral Fat Necrosis Following Therapeutic Hypothermia for Neonatal Encephalopathy"],"prefix":"10.1177","volume":"21","author":[{"given":"Salwa","family":"Khedr","sequence":"first","affiliation":[{"name":"Department of Pathology, Women and Infants Hospital, Providence, Rhode Island"},{"name":"Department of Pathology and Laboratory Medicine, Alpert Medical School, Brown University, Providence, Rhode Island"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Piskorski","sequence":"additional","affiliation":[{"name":"Department of Pathology, Women and Infants Hospital, Providence, Rhode Island"},{"name":"Department of Pathology and Laboratory Medicine, Alpert Medical School, Brown University, Providence, Rhode Island"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrienne R","family":"Bingham","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Women and Infants Hospital, Providence, Rhode Island"},{"name":"Department of Pediatrics, Alpert Medical School, Brown University, Providence, Rhode Island"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin","family":"Goldstein","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Women and Infants Hospital, Providence, Rhode Island"},{"name":"Department of Pediatrics, Alpert Medical School, Brown University, Providence, Rhode Island"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abbot R","family":"Laptook","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Women and Infants Hospital, Providence, Rhode Island"},{"name":"Department of Pediatrics, Alpert Medical School, Brown University, Providence, Rhode Island"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monique E","family":"De Paepe","sequence":"additional","affiliation":[{"name":"Department of Pathology, Women and Infants Hospital, Providence, Rhode Island"},{"name":"Department of Pathology and Laboratory Medicine, Alpert Medical School, Brown University, Providence, Rhode Island"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2017,11,6]]},"reference":[{"key":"bibr1-1093526617737881","doi-asserted-by":"crossref","unstructured":"Executive summary: neonatal encephalopathy and neurologic outcome, second edition. Report of the American College of Obstetricians and Gynecologists\u2019 Task Force on Neonatal Encephalopathy.\n                      Obstet Gynecol\n                      . 2014;123:896\u2013901.","DOI":"10.1097\/01.AOG.0000445580.65983.d2"},{"key":"bibr2-1093526617737881","doi-asserted-by":"crossref","unstructured":"Jacobs SE, Berg M, Hunt R, Tarnow-Mordi WO, Inder TE, Davis PG. 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