{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T11:39:39Z","timestamp":1784288379505,"version":"3.55.0"},"reference-count":28,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2018,3,16]],"date-time":"2018-03-16T00:00:00Z","timestamp":1521158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Pediatr Dev Pathol"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:p>Infantile choriocarcinoma (ICC) is a rare, highly malignant form of gestational trophoblastic neoplasia. Rapid diagnosis and initiation of treatment are paramount in reaching a successful outcome. Patients with these tumors typically present with a triad of anemia, hepatomegaly, and precocious puberty. Cutaneous manifestations of ICC are extraordinarily rare with few documented cases. Here, we describe a male neonate who presented to our Dermatology clinic with a rapidly growing, markedly vascular glabellar mass associated with abnormal laboratory values suggestive of Kasabach\u2013Merritt phenomenon. The initial clinical impression of infantile hemangioma led to an initial treatment with propranolol. However, the mass continued to enlarge and a biopsy was obtained. Histology revealed a high-grade, poorly differentiated carcinoma. A robust immunohistochemical battery demonstrated tumor reactivity with Glut-1, GATA3, Glypican-3, CAM5.2, and \u03b2-hCG establishing the diagnosis of metastatic choriocarcinoma. The diagnosis was further supported by the elevated serum \u03b2-hCG. In addition to the glabellar mass, imaging demonstrated tumor foci in the liver and lung. Clinical investigation of the mother revealed no evidence of disease.<\/jats:p>","DOI":"10.1177\/1093526618765039","type":"journal-article","created":{"date-parts":[[2018,3,16]],"date-time":"2018-03-16T08:00:59Z","timestamp":1521187259000},"page":"59-64","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Metastatic Choriocarcinoma Masquerading as a Congenital Glabellar Hemangioma"],"prefix":"10.1177","volume":"22","author":[{"given":"Steve","family":"Taylor","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Phoenix Children\u2019s Hospital, Phoenix, Arizona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly","family":"Eisenstein","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Phoenix Children\u2019s Hospital, Phoenix, Arizona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Gildenstern","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Phoenix Children\u2019s Hospital, Phoenix, Arizona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harper","family":"Price","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Phoenix Children\u2019s Hospital, Phoenix, Arizona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pooja","family":"Hingorani","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology, Phoenix Children\u2019s Hospital, Phoenix, Arizona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Apurvi","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology, Phoenix Children\u2019s Hospital, Phoenix, Arizona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan","family":"Page","sequence":"additional","affiliation":[{"name":"Department of Surgery, Phoenix Children\u2019s Hospital, Phoenix, Arizona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Smita","family":"Bailey","sequence":"additional","affiliation":[{"name":"Department of Radiology, Phoenix Children\u2019s Hospital, Phoenix, Arizona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Carpentieri","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Phoenix Children\u2019s Hospital, Phoenix, Arizona"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,3,16]]},"reference":[{"key":"bibr1-1093526618765039","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a114337"},{"key":"bibr2-1093526618765039","first-page":"155","volume":"39","author":"Palmer JR","year":"1994","journal-title":"J Reprod Med"},{"key":"bibr3-1093526618765039","first-page":"519","volume":"40","author":"Teoh ES","year":"1972","journal-title":"Obstet Gynaecol"},{"key":"bibr4-1093526618765039","unstructured":"Chang JW, Berek J. Gestational trophoblastic disease: epidemiology, clinical manifestations and diagnosis.\n                      Up to Date\n                      . Literature review current through: September 2013."},{"key":"bibr5-1093526618765039","unstructured":"Chang JW, Berek J. Gestational trophoblastic disease: epidemiology, clinical manifestations and diagnosis.\n                      Up to Date\n                      . Literature review current through: September 2013. Available at http:\/\/cursoenarm.net\/UPTODATE\/contents\/mobipreview.htm?3\/24\/3457?source=related_link."},{"key":"bibr6-1093526618765039","first-page":"39","volume-title":"Gestational Trophoblastic Diseases","author":"Smith HO","year":"2003","edition":"2"},{"key":"bibr7-1093526618765039","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(77)80113-5"},{"key":"bibr8-1093526618765039","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(68)80114-3"},{"key":"bibr9-1093526618765039","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-004-1212-x"},{"key":"bibr10-1093526618765039","doi-asserted-by":"publisher","DOI":"10.1080\/15227950590961180"},{"key":"bibr11-1093526618765039","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-003-1361-1"},{"key":"bibr12-1093526618765039","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1971.35.4.0465"},{"key":"bibr13-1093526618765039","doi-asserted-by":"publisher","DOI":"10.1016\/j.gynor.2012.05.002"},{"key":"bibr14-1093526618765039","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2006.08.007"},{"key":"bibr15-1093526618765039","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2011.01372.x"},{"key":"bibr16-1093526618765039","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e318212ecb3"},{"key":"bibr17-1093526618765039","doi-asserted-by":"publisher","DOI":"10.1053\/jpsu.2000.7846"},{"key":"bibr18-1093526618765039","first-page":"842751","volume":"2014","author":"Dhanda S","year":"2014","journal-title":"Radiol Res Pract"},{"key":"bibr19-1093526618765039","doi-asserted-by":"publisher","DOI":"10.1097\/00004728-199307000-00026"},{"key":"bibr20-1093526618765039","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-994102"},{"key":"bibr21-1093526618765039","doi-asserted-by":"publisher","DOI":"10.1007\/BF03178038"},{"key":"bibr22-1093526618765039","doi-asserted-by":"publisher","DOI":"10.1007\/s003300101004"},{"issue":"4","key":"bibr23-1093526618765039","doi-asserted-by":"crossref","first-page":"520","DOI":"10.5858\/2007-131-520-PFTEOS","volume":"131","author":"Finegold MJ","year":"2007","journal-title":"Arch Pathol Lab Med"},{"key":"bibr24-1093526618765039","doi-asserted-by":"publisher","DOI":"10.1186\/1752-1947-5-422"},{"key":"bibr25-1093526618765039","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-009-0864-1"},{"key":"bibr26-1093526618765039","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.20623"},{"key":"bibr27-1093526618765039","unstructured":"Pizzo PA, Poplock DG, eds.\n                      Principles and Practice of Pediatric Oncology\n                      . 4th ed. Philadelphia, PA: Lippincott Williams and Wilkins; 2002:1692."},{"key":"bibr28-1093526618765039","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2013.07.002"}],"container-title":["Pediatric and Developmental Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1093526618765039","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1093526618765039","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1093526618765039","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T04:04:45Z","timestamp":1777694685000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1093526618765039"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,16]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["10.1177\/1093526618765039"],"URL":"https:\/\/doi.org\/10.1177\/1093526618765039","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.732871127.793558465","asserted-by":"object"}]},"ISSN":["1093-5266","1615-5742"],"issn-type":[{"value":"1093-5266","type":"print"},{"value":"1615-5742","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,16]]}}}