{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T23:31:26Z","timestamp":1777937486592,"version":"3.51.4"},"reference-count":13,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2018,12,19]],"date-time":"2018-12-19T00:00:00Z","timestamp":1545177600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Pediatr Dev Pathol"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:p>A 7-year-old boy with a history of febrile illness-related epilepsy syndrome presented with proteinuria and elevated creatinine. His severe epileptic disorder has been treated since age 2 with multiple antiepileptic medications, including valproic acid. More recently, he was noted to have features of Fanconi syndrome with acidosis, hypophosphatemia, hypokalemia, glucosuria, and nephrotic-range proteinuria. This was managed with supplements; however, in the setting of rising creatinine and prominent proteinuria, a kidney biopsy was performed. Renal cortex revealed markedly decreased expression of proximal tubule markers and increased expression of markers of distal nephron differentiation. Such findings have been described in several genetic and acquired conditions, including renal tubular dysgenesis, severe hypoxic injury following renal artery stenosis, and toxic injury related to in utero exposure to angiotensin-converting-enzyme inhibitors. Such changes have not been reported before in valproic acid-associated Fanconi syndrome, although in general, morphologic findings in this condition have not been well established in the literature.<\/jats:p>","DOI":"10.1177\/1093526618819334","type":"journal-article","created":{"date-parts":[[2018,12,19]],"date-time":"2018-12-19T05:33:00Z","timestamp":1545197580000},"page":"370-374","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Kidney Biopsy Findings in a Patient With Valproic Acid-Associated Fanconi Syndrome"],"prefix":"10.1177","volume":"22","author":[{"given":"Pamela","family":"Singer","sequence":"first","affiliation":[{"name":"Pediatric Nephrology, Cohen Children\u2019s Medical Center of New York, Zucker School of Medicine, Hofstra University, Hempstead, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine B","family":"Sethna","sequence":"additional","affiliation":[{"name":"Pediatric Nephrology, Cohen Children\u2019s Medical Center of New York, Zucker School of Medicine, Hofstra University, Hempstead, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Castellanos-Reyes","sequence":"additional","affiliation":[{"name":"Pediatric Nephrology, Cohen Children\u2019s Medical Center of New York, Zucker School of Medicine, Hofstra University, Hempstead, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oksana","family":"Yaskiv","sequence":"additional","affiliation":[{"name":"Department of Pathology, Zucker School of Medicine, Hofstra University, Hempstead, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanesa","family":"Bijol","sequence":"additional","affiliation":[{"name":"Department of Pathology, Zucker School of Medicine, Hofstra University, Hempstead, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,12,19]]},"reference":[{"key":"bibr1-1093526618819334","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(81)80736-6"},{"key":"bibr2-1093526618819334","doi-asserted-by":"publisher","DOI":"10.3109\/15513819309048273"},{"key":"bibr3-1093526618819334","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-005-1827-7"},{"key":"bibr4-1093526618819334","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2009.12.003"},{"key":"bibr5-1093526618819334","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-013-2512-x"},{"key":"bibr6-1093526618819334","doi-asserted-by":"publisher","DOI":"10.1111\/nep.13012"},{"key":"bibr7-1093526618819334","doi-asserted-by":"publisher","DOI":"10.1007\/s100249900086"},{"key":"bibr8-1093526618819334","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-010-1584-0"},{"key":"bibr9-1093526618819334","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-013-2480-1"},{"key":"bibr10-1093526618819334","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420440503"},{"key":"bibr11-1093526618819334","doi-asserted-by":"publisher","DOI":"10.1007\/s100249900059"},{"key":"bibr12-1093526618819334","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(91)90036-O"},{"issue":"5","key":"bibr13-1093526618819334","first-page":"558","volume":"65","author":"Marcussen N","year":"1991","journal-title":"Lab Invest"}],"container-title":["Pediatric and Developmental Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1093526618819334","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1093526618819334","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1093526618819334","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T04:05:21Z","timestamp":1777694721000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1093526618819334"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,19]]},"references-count":13,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["10.1177\/1093526618819334"],"URL":"https:\/\/doi.org\/10.1177\/1093526618819334","relation":{},"ISSN":["1093-5266","1615-5742"],"issn-type":[{"value":"1093-5266","type":"print"},{"value":"1615-5742","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,19]]}}}