{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T23:31:50Z","timestamp":1777937510802,"version":"3.51.4"},"reference-count":3,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"VIVA-KKH Paediatric Brain and Solid Tumours Programme"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Pediatr Dev Pathol"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:p>We describe the clinical, pathological, and molecular features of a primary adrenal angiomatoid fibrous histiocytoma (AFH) in an 11-year-old girl presenting with pyrexia of unknown origin. We performed next-generation sequencing-based anchored multiplex polymerase chain reaction (Archer\u00ae FusionPlex\u00ae sarcoma assay), which revealed an EWSR1-ATF1 gene fusion with novel breakpoints in exon 11 of EWSR1 and exon 3 of ATF1. The pyrexia resolved fully after surgical resection, and the patient was disease-free on follow-up at 1 year and 6 months. This case exemplifies the value of molecular testing of pediatric neoplasms presenting at unusual sites for diagnosis and identification of novel gene fusion breakpoints.<\/jats:p>","DOI":"10.1177\/1093526619830287","type":"journal-article","created":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T21:56:36Z","timestamp":1551477396000},"page":"472-474","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Primary Adrenal Angiomatoid Fibrous Histiocytoma With Novel\n                    <i>EWSR1-ATF1<\/i>\n                    Gene Fusion Exon\u2013Exon Breakpoint"],"prefix":"10.1177","volume":"22","author":[{"given":"Irfan Sagir","family":"Khan","sequence":"first","affiliation":[{"name":"Department of Pathology, National\r                University Health System, Singapore, Republic of Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chik Hong","family":"Kuick","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory\r                Medicine, KK Women\u2019s and Children\u2019s Hospital, Singapore, Republic of Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sudhanshi","family":"Jain","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory\r                Medicine, KK Women\u2019s and Children\u2019s Hospital, Singapore, Republic of Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7103-6807","authenticated-orcid":false,"given":"Derrick","family":"Wen Quan Lian","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory\r                Medicine, KK Women\u2019s and Children\u2019s Hospital, Singapore, Republic of Singapore"},{"name":"Duke-NUS\r                Medical School, Singapore, Republic of\r                Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amos","family":"Hong Pheng Loh","sequence":"additional","affiliation":[{"name":"Duke-NUS\r                Medical School, Singapore, Republic of\r                Singapore"},{"name":"Department of Pediatric Surgery, KK\r                Women\u2019s and Children\u2019s Hospital, Singapore, Republic of Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ah Moy","family":"Tan","sequence":"additional","affiliation":[{"name":"Duke-NUS\r                Medical School, Singapore, Republic of\r                Singapore"},{"name":"Hematology-Oncology Service, KK Women\u2019s\r                and Children\u2019s Hospital, Singapore, Republic of Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5244-4285","authenticated-orcid":false,"given":"Kenneth","family":"Tou-En Chang","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory\r                Medicine, KK Women\u2019s and Children\u2019s Hospital, Singapore, Republic of Singapore"},{"name":"Duke-NUS\r                Medical School, Singapore, Republic of\r                Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,3,1]]},"reference":[{"key":"bibr1-1093526619830287","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2011.126"},{"key":"bibr2-1093526619830287","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.20491"},{"key":"bibr3-1093526619830287","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.20881"}],"container-title":["Pediatric and Developmental Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1093526619830287","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1093526619830287","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1093526619830287","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T04:05:31Z","timestamp":1777694731000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1093526619830287"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,1]]},"references-count":3,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["10.1177\/1093526619830287"],"URL":"https:\/\/doi.org\/10.1177\/1093526619830287","relation":{},"ISSN":["1093-5266","1615-5742"],"issn-type":[{"value":"1093-5266","type":"print"},{"value":"1615-5742","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,1]]}}}