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Children\u2019s Hepatic International Collaboration (CHIC), Children\u2019s Oncology Group (COG), Soci\u00e9t\u00e9Internationale d\u2019Oncologie P\u00e9diatrique (SIOP), and International Childhood Liver Tumors Strategy Group trials have contributed to define prognostic factors and risk stratification in these tumors. The recently proposed histologic International Consensus classification of HB and HCC in children based on retrospective analysis from CHIC cases represents the base to define entities with homogeneous clinicopathologic and molecular features. This review will provide a morphologic guide for the upcoming International Liver Tumor treatment trial (Pediatric Hepatic International Tumour Trial) to be conducted through several continents. There will be an emphasis on molecular features and immunohistochemical markers for the definition of the individual histologic subtypes of HB and to better characterize the group of liver tumors in the provisional category of hepatocellular neoplasm\u2014not otherwise specified. A brief overview of HCC in children will also be provided.<\/jats:p>","DOI":"10.1177\/1093526619875228","type":"journal-article","created":{"date-parts":[[2019,9,26]],"date-time":"2019-09-26T00:19:26Z","timestamp":1569457166000},"page":"79-95","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":196,"title":["Hepatoblastoma and Pediatric Hepatocellular Carcinoma: An Update"],"prefix":"10.1177","volume":"23","author":[{"given":"Sarangarajan","family":"Ranganathan","sequence":"first","affiliation":[{"name":"Department of Pathology, UPMC Children\u2019s Hospital of Pittsburgh, Pittsburgh, Pennsylvania"},{"name":"Department of Pathology, Texas Children\u2019s Hospital and Baylor College of Medicine, Houston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dolores","family":"Lopez-Terrada","sequence":"additional","affiliation":[{"name":"Department of Pathology, UPMC Children\u2019s Hospital of 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