{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T23:30:45Z","timestamp":1777937445040,"version":"3.51.4"},"reference-count":17,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2019,10,16]],"date-time":"2019-10-16T00:00:00Z","timestamp":1571184000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Pediatr Dev Pathol"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The clinical significance of a diagnosis of granulomatous appendicitis (GA) is not well established in the pediatric population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective review of the etiology and histopathology of pediatric GA at 2 large pediatric institutions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Forty-three (0.4%) patients had GA at a median age of 12.1 years. Twenty-two (51%) had perforated appendicitis that was medically managed prior to interval appendectomy. Sixteen of 21 noninterval appendectomies were performed for clinically suspected acute appendicitis. Among them, 1 had Crohn\u2019s disease identified during surgery. None of the other patients had a subsequent diagnosis of inflammatory bowel disease (median follow-up of 4 weeks). There were significantly more cases with mucosal-only granulomas as well as fewer serosal granulomas in the noninterval appendectomy specimens than the interval specimens ( P\u2009=\u2009.014). When performed, special stains for microorganisms did not contribute to clinical care. In the same time period, GA was seen in 6 (6%) of 94 bowel resections for Crohn\u2019s disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>GA is rare in pediatric patients, with interval appendectomy being the most common etiology and only rarely associated with Crohn\u2019s disease. Granulomas in interval appendectomies tend to be serosal-based. Special stains for infectious organisms in GA are of low diagnostic yield and have little impact on clinical management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1093526619881545","type":"journal-article","created":{"date-parts":[[2019,10,17]],"date-time":"2019-10-17T00:32:43Z","timestamp":1571272363000},"page":"215-221","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Granulomatous Appendicitis in the Pediatric Population"],"prefix":"10.1177","volume":"23","author":[{"given":"Hao","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Pathology and Immunology, Baylor College of Medicine, Texas Children\u2019s Hospital, Houston, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maren Y","family":"Fuller","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology, Baylor College of Medicine, Texas Children\u2019s Hospital, Houston, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Pogoriler","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Children\u2019s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,10,16]]},"reference":[{"key":"bibr1-1093526619881545","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200104000-00011"},{"key":"bibr2-1093526619881545","doi-asserted-by":"publisher","DOI":"10.1177\/1066896909349246"},{"key":"bibr3-1093526619881545","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.36.6.632"},{"issue":"6","key":"bibr4-1093526619881545","first-page":"592","volume":"71","author":"Jacobson S","year":"1979","journal-title":"Am J Gastroenterol"},{"key":"bibr5-1093526619881545","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(86)80416-6"},{"key":"bibr6-1093526619881545","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200308000-00013"},{"key":"bibr7-1093526619881545","volume-title":"Polymicrobial Diseases","author":"Jenkinson HF","year":"2002","edition":"1"},{"key":"bibr8-1093526619881545","volume-title":"Medical Microbiology","author":"Gorbach SL","year":"1996","edition":"4"},{"key":"bibr9-1093526619881545","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.26.3.582-583.1988"},{"key":"bibr10-1093526619881545","doi-asserted-by":"publisher","DOI":"10.4061\/2011\/182051"},{"key":"bibr11-1093526619881545","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-13-236"},{"key":"bibr12-1093526619881545","unstructured":"Centers for Disease Control and Prevention.\n                      Yersinia Enterocolitica (Yersiniosis): Diagnosis and Treatment\n                      . https:\/\/www.cdc.gov\/yersinia\/diagnosis.html. 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