{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T18:36:50Z","timestamp":1793644610576,"version":"4.5.1"},"reference-count":84,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2019,11,20]],"date-time":"2019-11-20T00:00:00Z","timestamp":1574208000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Pediatr Dev Pathol"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p>Endorectal pullthrough surgery is integral in the treatment of patients with Hirschsprung disease. Several different surgical procedures exist, which share as common goals to excise the aganglionic segment and upstream transition zone and attach ganglionic bowel just proximal to the anal canal. The operation requires collaboration between surgeon and pathologist to localize ganglionic bowel and prevent retention of transition zone. Intraoperative frozen sections are extremely important, first to establish that ganglion cells are present and subsequently to exclude features of transition zone (partial circumferential aganglionosis, myenteric hypoganglionosis, and submucosal nerve hypertrophy) at the proximal surgical (anastomotic) margin. Postoperative histopathological analysis of resection specimens should be tailored to document distal aganglionosis, document the length of the aganglionic segment and its proximity to the anastomotic margin, and confirm that transition zone has been resected completely. Adherence to the recommendations described in this review will reduce the likelihood of transition zone pullthrough and should decrease the incidence of persistent postoperative obstructive symptoms.<\/jats:p>","DOI":"10.1177\/1093526619889436","type":"journal-article","created":{"date-parts":[[2019,11,21]],"date-time":"2019-11-21T00:44:01Z","timestamp":1574297041000},"page":"23-39","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":47,"title":["Surgery, Surgical Pathology, and Postoperative Management of Patients With Hirschsprung Disease"],"prefix":"10.1177","volume":"23","author":[{"given":"Caitlin","family":"Smith","sequence":"first","affiliation":[{"name":"Department of Pediatric Surgery, Seattle Children\u2019s Hospital and University of Washington, Seattle, Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lusine","family":"Ambartsumyan","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Seattle Children\u2019s Hospital and University of Washington, Seattle, Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raj P","family":"Kapur","sequence":"additional","affiliation":[{"name":"Department of Pathology, Seattle Children\u2019s Hospital and University of Washington, Seattle, Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,11,20]]},"reference":[{"key":"bibr1-1093526619889436","first-page":"207","volume":"26","author":"Frongia G","year":"2016","journal-title":"Eur J Pediatr Surg"},{"key":"bibr2-1093526619889436","doi-asserted-by":"publisher","DOI":"10.1016\/jpsu.2003.50165"},{"key":"bibr3-1093526619889436","first-page":"212","volume":"24","author":"Swenson O","year":"1948","journal-title":"Surgery"},{"key":"bibr4-1093526619889436","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(98)90515-2"},{"key":"bibr5-1093526619889436","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(00)00487-6"},{"key":"bibr6-1093526619889436","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2004.09.033"},{"key":"bibr7-1093526619889436","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-011-2960-y"},{"key":"bibr8-1093526619889436","doi-asserted-by":"publisher","DOI":"10.1055\/s-0035-1552559"},{"key":"bibr9-1093526619889436","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-199809000-00017"},{"key":"bibr10-1093526619889436","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(86)80006-9"},{"key":"bibr11-1093526619889436","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-010-2692-4"},{"key":"bibr12-1093526619889436","doi-asserted-by":"publisher","DOI":"10.1053\/j.sempedsurg.2012.07.003"},{"key":"bibr13-1093526619889436","doi-asserted-by":"publisher","DOI":"10.2350\/12-12-1282-OA.1"},{"key":"bibr14-1093526619889436","doi-asserted-by":"publisher","DOI":"10.2350\/11-02-0977-OA.1"},{"key":"bibr15-1093526619889436","first-page":"1007","volume":"56","author":"Soave F","year":"1964","journal-title":"Surgery"},{"key":"bibr16-1093526619889436","first-page":"571","volume-title":"Operative Pediatric Surgery","author":"Teitelbaum DH","year":"2014"},{"key":"bibr17-1093526619889436","unstructured":"Chen M, Zigman A, Gosain A.\n                      Pull through for Hirschsprung disease\n                      . 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