{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:36:15Z","timestamp":1787164575169,"version":"build-2736575974"},"reference-count":41,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2020,3,8]],"date-time":"2020-03-08T00:00:00Z","timestamp":1583625600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"March of Dimes Prematurity Research Collaborative of Ohio","award":["not applicable"],"award-info":[{"award-number":["not applicable"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Pediatr Dev Pathol"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:p>Indications for placental submission are variable. Established guidelines are largely based on expert opinion, and there is a need for more evidence-based criteria. A 10-year database of term placentas was used to evaluate indications significantly associated with placental pathology. Lesions in 5 categories were separated into high- and low-grade subgroups. Two additional high-grade lesions were also evaluated. Indications associated with high-grade placental lesions were chronic monitoring abnormalities, severe preeclampsia, pregestational diabetes, maternal signs of infection, postdates pregnancy, artificial reproductive technology, drug abuse, umbilical cord entanglements, selected gross placental abnormalities, stillbirth, Apgar 5 minutes &lt;6, small-for-gestational age infant, and macrosomia. Indications for which placental findings did not differ from the population as a whole were acute monitoring abnormalities, chronic hypertension, maternal obesity, vaginal bleeding, accessory lobe\/multilobed placenta, meconium-stained fluid, single umbilical artery, and borderline large-for-gestational age infant. Other indications for submission were intermediate showing significant or borderline elevations in the prevalence of low- and high-grade lesions combined. We suggest on the basis of this study that guidelines for the submission of singleton term placentas could be modified to exclude cases with clinical indications that lack a significant association with placental lesions.<\/jats:p>","DOI":"10.1177\/1093526620904801","type":"journal-article","created":{"date-parts":[[2020,3,9]],"date-time":"2020-03-09T00:11:13Z","timestamp":1583712673000},"page":"274-284","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":35,"title":["Predictors of High Grade and Other Clinically Significant Placental Findings by Indication for Submission in Singleton Placentas From Term Births"],"prefix":"10.1177","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4997-3412","authenticated-orcid":false,"given":"Yi Yuan","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Pathology, University Hospitals Cleveland Medical Center, Cleveland, Ohio"},{"name":"School of Medicine, Case Western Reserve University, Cleveland, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7268-6000","authenticated-orcid":false,"given":"Sanjita","family":"Ravishankar","sequence":"additional","affiliation":[{"name":"Department of Pathology, University Hospitals Cleveland Medical Center, Cleveland, Ohio"},{"name":"School of Medicine, Case Western Reserve University, Cleveland, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangju","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Pathology, University Hospitals Cleveland Medical Center, Cleveland, Ohio"},{"name":"School of Medicine, Case Western Reserve University, Cleveland, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond W","family":"Redline","sequence":"additional","affiliation":[{"name":"Department of Pathology, University Hospitals Cleveland Medical Center, Cleveland, Ohio"},{"name":"School of Medicine, Case Western Reserve University, Cleveland, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,3,8]]},"reference":[{"key":"bibr1-1093526620904801","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2015.05.056"},{"key":"bibr2-1093526620904801","first-page":"449","volume":"121","author":"Langston C","year":"1997","journal-title":"Arch Pathol Lab Med"},{"key":"bibr3-1093526620904801","unstructured":"Cox P, Evans C. Royal College of Pathologist: tissue pathway for examination of the placenta. https:\/\/www.rcpath.org\/uploads\/assets\/ec614dfa-007c-4a93-8173cb202a071a72\/G108-Tissue-pathway-for-histopathological-examination-of-the-placenta.pdf. Published July 7, 2017."},{"issue":"2","key":"bibr4-1093526620904801","doi-asserted-by":"crossref","first-page":"205","DOI":"10.5858\/2003-127-205-CTGFPE","volume":"127","author":"Spencer MK","year":"2003","journal-title":"Arch Pathol Lab Med"},{"key":"bibr5-1093526620904801","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000247646.19979.9f"},{"key":"bibr6-1093526620904801","unstructured":"Redline RW. Appendix 9: means and standard deviations for placental weights and dimensions, birth weights, and fetoplacental weight ratios for gestational age. In: Redline RW, Boyd TK, Roberts DJ, eds.\n                      Placental and Gestational Pathology\n                      . Cambridge, England: Cambridge University Press; 2018."},{"key":"bibr7-1093526620904801","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2015-0225-CC"},{"key":"bibr8-1093526620904801","doi-asserted-by":"crossref","unstructured":"Khong TY, Mooney EE, Nikkels PGJ, Morgan TK, Gordijn S, eds.\n                      Pathology of the Placenta: A Practical Guide\n                      . 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