{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T23:31:49Z","timestamp":1777937509828,"version":"3.51.4"},"reference-count":14,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2020,8,5]],"date-time":"2020-08-05T00:00:00Z","timestamp":1596585600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Pediatr Dev Pathol"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Pathologic examination of conduction system (CS) is not routinely performed, and histologic changes are mostly reported in forensic practice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We studied the value of dissecting the CS in a cohort of pediatric patients with unexplained sudden death or severe, inexplicable arrhythmias. Histopathologic changes present in CS components were recorded and correlated with findings noted in other cardiac structures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twenty-one subjects (11 unexplained sudden deaths and 10 life-threatening arrhythmias) were identified; 18 (86%) had CS pathologic abnormalities. In 13 patients (62%), the CS findings mirrored those found in other cardiac sections (inflammation, allograft vasculopathy, vascular fibromuscular dysplasia, cardiomyopathy-related changes, and tumor\/tumor-like conditions). Five cases (24%) had abnormalities restricted to CS (bundle of His [BH] with fibrotic scar and patch material following ventricular septal defect repair, inflammation, BH with fibrosis and calcifications, and intimal fibroplasia of sinoatrial node artery).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Pathologic changes within the CS are present in a high number of pediatric patients presenting with unexplained sudden death or life-threatening arrhythmias. Frequently, the findings mirror those observed in other cardiac structures. However, in a significant number of cases (24%), the changes are restricted to CS and likely explain the patients\u2019 symptoms or cause of death, suggesting that systematic dissection of CS unveils valuable information.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1093526620944756","type":"journal-article","created":{"date-parts":[[2020,8,5]],"date-time":"2020-08-05T14:15:40Z","timestamp":1596636940000},"page":"413-423","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Dissecting the Cardiac Conduction System: Is It Worthwhile?"],"prefix":"10.1177","volume":"23","author":[{"given":"Serena Y","family":"Tan","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Ann & Robert H. Lurie Children\u2019s Hospital of Chicago, Chicago, Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael K","family":"Fritsch","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven","family":"White","sequence":"additional","affiliation":[{"name":"British Columbia Coroners Service, Vancouver, British Columbia, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicoleta C","family":"Arva","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Ann & Robert H. Lurie Children\u2019s Hospital of Chicago, Chicago, Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,8,5]]},"reference":[{"key":"bibr1-1093526620944756","doi-asserted-by":"publisher","DOI":"10.1002\/ca.20700"},{"key":"bibr2-1093526620944756","doi-asserted-by":"publisher","DOI":"10.1007\/s12265-012-9433-0"},{"key":"bibr3-1093526620944756","doi-asserted-by":"publisher","DOI":"10.1007\/978-88-470-5776-0"},{"key":"bibr4-1093526620944756","doi-asserted-by":"publisher","DOI":"10.1016\/j.carpath.2016.08.005"},{"key":"bibr5-1093526620944756","doi-asserted-by":"publisher","DOI":"10.1136\/jclinpath-2011-200366"},{"key":"bibr6-1093526620944756","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ker515"},{"key":"bibr7-1093526620944756","doi-asserted-by":"publisher","DOI":"10.1016\/j.carpath.2013.07.001"},{"key":"bibr8-1093526620944756","doi-asserted-by":"publisher","DOI":"10.1097\/00000433-200203000-00018"},{"key":"bibr9-1093526620944756","doi-asserted-by":"publisher","DOI":"10.1016\/j.forsciint.2014.10.004"},{"key":"bibr10-1093526620944756","doi-asserted-by":"publisher","DOI":"10.3390\/biology6010007"},{"key":"bibr11-1093526620944756","doi-asserted-by":"publisher","DOI":"10.1016\/j.carpath.2007.07.009"},{"key":"bibr12-1093526620944756","doi-asserted-by":"publisher","DOI":"10.1016\/S1054-8807(00)00035-1"},{"key":"bibr13-1093526620944756","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(68)90154-9"},{"key":"bibr14-1093526620944756","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(85)80022-X"}],"container-title":["Pediatric and Developmental Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1093526620944756","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1093526620944756","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1093526620944756","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T04:06:48Z","timestamp":1777694808000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1093526620944756"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,5]]},"references-count":14,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["10.1177\/1093526620944756"],"URL":"https:\/\/doi.org\/10.1177\/1093526620944756","relation":{},"ISSN":["1093-5266","1615-5742"],"issn-type":[{"value":"1093-5266","type":"print"},{"value":"1615-5742","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,5]]}}}