{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T23:31:10Z","timestamp":1777937470730,"version":"3.51.4"},"reference-count":11,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2020,9,24]],"date-time":"2020-09-24T00:00:00Z","timestamp":1600905600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Pediatr Dev Pathol"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>Methadone, an opioid agonist, is the recommended treatment for pregnant women with opioid use disorder (OUD). Fetal\/neonatal autopsy findings as well as placental changes in the setting of maternal OUD or methadone maintenance therapy (MMT) are not well-characterized. Here we present a case of a neonate who had exposure to MMT while in utero and died shortly after birth and was subsequently found to have multifocal calcified renal vein thrombosis, a recent inferior vena cava thrombus, and placental features of fetal vascular malperfusion at autopsy.<\/jats:p>","DOI":"10.1177\/1093526620962062","type":"journal-article","created":{"date-parts":[[2020,9,24]],"date-time":"2020-09-24T16:08:42Z","timestamp":1600963722000},"page":"56-61","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Thrombosis of the Renal Vein and Inferior Vena Cava Associated With Placental Fetal Vascular Malperfusion in a Neonate Exposed to Methadone Maintenance Therapy In Utero"],"prefix":"10.1177","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7876-6602","authenticated-orcid":false,"given":"J C","family":"Guerrero","sequence":"first","affiliation":[{"name":"Department of Pathology, The Children\u2019s Hospital of Philadelphia, Philadelphia, Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1773-0758","authenticated-orcid":false,"given":"Joseph","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariarita","family":"Santi","sequence":"additional","affiliation":[{"name":"Department of Pathology, The Children\u2019s Hospital of Philadelphia and Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo","family":"Ruchelli","sequence":"additional","affiliation":[{"name":"Department of Pathology, The Children\u2019s Hospital of Philadelphia and Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chrystalle Katte","family":"Carreon","sequence":"additional","affiliation":[{"name":"Department of Pathology, The Children\u2019s Hospital of Philadelphia and Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania"},{"name":"Department of Pathology, Boston Children\u2019s Hospital and Harvard Medical School, Boston, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,9,24]]},"reference":[{"key":"bibr1-1093526620962062","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2016.12.016"},{"key":"bibr2-1093526620962062","doi-asserted-by":"publisher","DOI":"10.1186\/s40064-016-3757-1"},{"key":"bibr3-1093526620962062","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2020.02.014"},{"key":"bibr4-1093526620962062","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2011.08.004"},{"key":"bibr5-1093526620962062","doi-asserted-by":"publisher","DOI":"10.1016\/j.pedneo.2017.09.009"},{"key":"bibr6-1093526620962062","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aes447"},{"key":"bibr7-1093526620962062","doi-asserted-by":"publisher","DOI":"10.1111\/apa.13046"},{"key":"bibr8-1093526620962062","doi-asserted-by":"publisher","DOI":"10.1186\/s13256-017-1414-0"},{"key":"bibr9-1093526620962062","first-page":"79","volume":"6","author":"van der Schier R","journal-title":"F1000Prime Rep"},{"key":"bibr10-1093526620962062","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2017-0212-RA"},{"key":"bibr11-1093526620962062","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcjd.2019.07.152"}],"container-title":["Pediatric and Developmental Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1093526620962062","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1093526620962062","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1093526620962062","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T04:06:59Z","timestamp":1777694819000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1093526620962062"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,24]]},"references-count":11,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1177\/1093526620962062"],"URL":"https:\/\/doi.org\/10.1177\/1093526620962062","relation":{},"ISSN":["1093-5266","1615-5742"],"issn-type":[{"value":"1093-5266","type":"print"},{"value":"1615-5742","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,24]]}}}