{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T22:26:59Z","timestamp":1793831219361,"version":"4.6.1"},"reference-count":36,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2021,4,19]],"date-time":"2021-04-19T00:00:00Z","timestamp":1618790400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Pediatr Dev Pathol"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Acute myocarditis is an inflammatory disease of the heart mostly diagnosed in young people, which can present as sudden death. The etiology includes infectious agents (mostly viruses), systemic diseases and toxins. We aim to characterize infants and children with myocarditis at post-mortem presenting as sudden deaths.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective evaluation of 813 post-mortems in infants and children dying suddenly and unexpectedly between 2009\u20132019. Data retrieved included histological features, microbiology and clinical history.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>23 of 813 post-mortems reviewed corresponded to acute myocarditis and 1 to dilated cardiomyopathy related to remote Parvovirus infection. PCR identified enterovirus (7), parvovirus (7 cases, 2 also with HHV6 and 1 case with EVB), Influenza A (1), Parainfluenza type 3 (1). Two cases corresponded to hypersensitivity myocarditis, 1 was Group A Streptococcus and 5 idiopathic myocarditis. Enterovirus was frequent in infants (7\/10), and in newborns was associated with meningoencephalitis or congenital myocarditis. More than 50% were less than 2 years of age and all remained clinically unsuspected.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Myocarditis represents almost 3% of all sudden pediatric deaths. Enterovirus and parvovirus were the most common viruses. This retrospective analysis showed that patients experienced viral symptoms but remained unsuspected, highlighting the need for more clinical awareness of myocarditis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10935266211007262","type":"journal-article","created":{"date-parts":[[2021,4,19]],"date-time":"2021-04-19T16:17:01Z","timestamp":1618849021000},"page":"327-336","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":24,"title":["Myocarditis Presenting as Sudden Death in Infants and Children: A Single Centre Analysis by ESGFOR Study Group"],"prefix":"10.1177","volume":"24","author":[{"given":"Oana","family":"Neagu","sequence":"first","affiliation":[{"name":"Histopathology Department, Sheffield Children\u2019s NHS FT, Sheffield, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amparo Fern\u00e1ndez","family":"Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Forensic Microbiology Laboratory, Instituto Nacional de Toxicolog\u00eda y Ciencias Forenses, Madrid, Spain"},{"name":"Joint Working Group of the European Society of Clinical Microbiology and Infectious Diseases Study Group of Forensic and Postmortem Microbiology and the European Society of Pathology, Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domitille","family":"Callon","sequence":"additional","affiliation":[{"name":"Joint Working Group of the European Society of Clinical Microbiology and Infectious Diseases Study Group of Forensic and Postmortem Microbiology and the European Society of Pathology, Basel, Switzerland"},{"name":"Clinical and Molecular Virology Unit, Centre Hospitalier Universitaire, Reims, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Andr\u00e9oletti","sequence":"additional","affiliation":[{"name":"Joint Working Group of the European Society of Clinical Microbiology and Infectious Diseases Study Group of Forensic and Postmortem Microbiology and the European Society of Pathology, Basel, Switzerland"},{"name":"Clinical and Molecular Virology Unit, Centre Hospitalier Universitaire, Reims, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5534-444X","authenticated-orcid":false,"given":"Marta C","family":"Cohen","sequence":"additional","affiliation":[{"name":"Histopathology Department, Sheffield Children\u2019s NHS FT, Sheffield, UK"},{"name":"Joint Working Group of the European Society of Clinical Microbiology and Infectious Diseases Study Group of Forensic and Postmortem Microbiology and the European Society of Pathology, Basel, Switzerland"},{"name":"Department of Oncology and Metabolism, University of Sheffield, Sheffield, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,4,19]]},"reference":[{"issue":"9","key":"bibr1-10935266211007262","first-page":"779","volume":"59","author":"Kindermann I","year":"2012","journal-title":"JAC"},{"key":"bibr2-10935266211007262","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60648-X"},{"key":"bibr3-10935266211007262","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(87)80363-5"},{"key":"bibr4-10935266211007262","doi-asserted-by":"publisher","DOI":"10.1016\/j.carpath.2011.10.001"},{"key":"bibr5-10935266211007262","doi-asserted-by":"publisher","DOI":"10.17265\/2159-5313\/2016.09.003"},{"key":"bibr6-10935266211007262","unstructured":"Confidential Enquiry into Maternal and Child Health, Scottish Cot Death Trust. 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