{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T23:32:18Z","timestamp":1777937538147,"version":"3.51.4"},"reference-count":47,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2021,5,17]],"date-time":"2021-05-17T00:00:00Z","timestamp":1621209600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Pediatr Dev Pathol"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To investigate the correlation between prenatal ultrasound (US) and autopsy findings in pregnancies terminated due to isolated congenital heart defects (CHDs), including CHDs associated with heterotaxy syndrome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>The material consists of 67 fetuses with prenatally detected isolated CHDs or CHDs associated with heterotaxy syndrome at a tertiary center in Norway between 1985 and 2014. The main CHDs were categorized into subdiagnoses of CHDs in accordance with ICD-10. The US and autopsy findings were categorized according to degree of concordance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Gestational age at termination was 12\u2009+\u20090\u201322\u2009+\u20096 weeks. Hypoplastic left heart syndrome was the most common main diagnosis among the 67 fetuses (32.8%). There was full agreement between US and autopsy findings in 97.4% (222\/228) of all subdiagnoses. The discrepant findings in three fetuses had no influence on the decision to terminate the pregnancy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The correlation was high between prenatal US and postmortem findings in fetuses with isolated CHDs. Meticulous assessment of cardiac anatomy is particularly necessary when the decision to terminate relies on isolated CHDs. The trend of earlier termination challenges verification of diagnoses at autopsy. Consequently, the fetus should be examined at a tertiary center with fetal medicine specialists, pediatric cardiologists and perinatal pathologists.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10935266211016184","type":"journal-article","created":{"date-parts":[[2021,5,17]],"date-time":"2021-05-17T03:26:08Z","timestamp":1621221968000},"page":"422-429","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Postmortem Assessment of Isolated Congenital Heart Defects Remains Essential Following Termination of Pregnancy"],"prefix":"10.1177","volume":"24","author":[{"given":"Camilla","family":"Struksn\u00e6s","sequence":"first","affiliation":[{"name":"Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harm-Gerd K","family":"Blaas","sequence":"additional","affiliation":[{"name":"Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway"},{"name":"National Center for Fetal Medicine, Department of Obstetrics and Gynecology, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sturla H","family":"Eik-Nes","sequence":"additional","affiliation":[{"name":"Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway"},{"name":"National Center for Fetal Medicine, Department of Obstetrics and Gynecology, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Tegnander","sequence":"additional","affiliation":[{"name":"Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway"},{"name":"National Center for Fetal Medicine, Department of Obstetrics and Gynecology, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"Vogt","sequence":"additional","affiliation":[{"name":"Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway"},{"name":"Department of Pathology, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,5,17]]},"reference":[{"key":"bibr1-10935266211016184","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970060108"},{"key":"bibr2-10935266211016184","doi-asserted-by":"publisher","DOI":"10.3109\/15513818909022327"},{"key":"bibr3-10935266211016184","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1999.13020117.x"},{"key":"bibr4-10935266211016184","doi-asserted-by":"publisher","DOI":"10.1002\/uog.10106"},{"key":"bibr5-10935266211016184","doi-asserted-by":"publisher","DOI":"10.1002\/uog.15773"},{"key":"bibr6-10935266211016184","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2016.12.024"},{"key":"bibr7-10935266211016184","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1995.05060372.x"},{"key":"bibr8-10935266211016184","doi-asserted-by":"publisher","DOI":"10.1002\/uog.2710"},{"key":"bibr9-10935266211016184","unstructured":"WHO.net: International Statistical Classification of Diseases and Related Health Problems 10th Revision (ICD-10). https:\/\/icd.who.int\/browse10\/2019\/en#\/Q20-Q28. 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