{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T23:32:12Z","timestamp":1777937532888,"version":"3.51.4"},"reference-count":10,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2021,9,14]],"date-time":"2021-09-14T00:00:00Z","timestamp":1631577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Pediatr Dev Pathol"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:p>Cellular fibroma of tendon sheath (CFTS) is a rare, benign myofibroblastic neoplasm of tenosynovial soft tissues closely resembling nodular fasciitis (NF), but is histomorphologically distinct from classic fibroma of tendon sheath (FTS). We report a case of a pediatric patient with thumb swelling clinically concerning for arthritis with a biopsy demonstrating myofibroblastic proliferation with features consistent with NF\/CFTS, and molecular studies confirming the presence of a USP6 gene fusion (TNC-USP6). This case highlights a unique clinical presentation of CFTS in a pediatric patient mimicking an inflammatory or reactive\/non-neoplastic musculoskeletal disorder and the increasingly crucial role of molecular testing to differentiate a reactive myofibroblastic process from a neoplasm. Moreover, this report identifies TNC as a new fusion partner to USP6 fusion partner adding to our growing understanding of the USP6-rearranged family of tumors.<\/jats:p>","DOI":"10.1177\/10935266211043869","type":"journal-article","created":{"date-parts":[[2021,9,14]],"date-time":"2021-09-14T17:06:21Z","timestamp":1631639181000},"page":"192-196","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Cellular Fibroma of Tendon Sheath With Novel\n                    <i>TNC-USP6<\/i>\n                    Gene Fusion Clinically Mimicking Arthritis in a 7-Year-Old Boy"],"prefix":"10.1177","volume":"25","author":[{"given":"Joshua M","family":"Eisenberg","sequence":"first","affiliation":[{"name":"Department of Orthopedics and Rehabilitation, University of Iowa, Iowa City, Iowa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph A","family":"Buckwalter V","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Rehabilitation, University of Iowa, Iowa City, Iowa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony N","family":"Snow","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Iowa, Iowa City, Iowa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Davick","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Iowa, Iowa City, Iowa"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,9,14]]},"reference":[{"key":"bibr1-10935266211043869","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197911)44:5<1945::AID-CNCR2820440558>3.0.CO;2-T"},{"key":"bibr2-10935266211043869","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2016.83"},{"key":"bibr3-10935266211043869","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-020-0621-1"},{"key":"bibr4-10935266211043869","doi-asserted-by":"publisher","DOI":"10.1177\/1066896920908054"},{"key":"bibr5-10935266211043869","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2011.118"},{"key":"bibr6-10935266211043869","doi-asserted-by":"publisher","DOI":"10.1016\/j.jos.2018.12.008"},{"key":"bibr7-10935266211043869","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.22836"},{"key":"bibr8-10935266211043869","doi-asserted-by":"publisher","DOI":"10.1016\/S0945-053X(00)00106-2"},{"key":"bibr9-10935266211043869","doi-asserted-by":"publisher","DOI":"10.1016\/S1357-2725(97)00031-9"},{"key":"bibr10-10935266211043869","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2017.78"}],"container-title":["Pediatric and Developmental Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10935266211043869","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10935266211043869","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10935266211043869","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T04:08:05Z","timestamp":1777694885000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10935266211043869"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,14]]},"references-count":10,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["10.1177\/10935266211043869"],"URL":"https:\/\/doi.org\/10.1177\/10935266211043869","relation":{},"ISSN":["1093-5266","1615-5742"],"issn-type":[{"value":"1093-5266","type":"print"},{"value":"1615-5742","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,14]]}}}