{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T17:30:20Z","timestamp":1781631020858,"version":"3.54.5"},"reference-count":25,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2021,11,18]],"date-time":"2021-11-18T00:00:00Z","timestamp":1637193600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Pediatr Dev Pathol"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Hypertrophic submucosal nerves, defined as \u226540\u2009\u00b5m in diameter, are considered supportive of a diagnosis of HSCR, but the effect of age on nerve diameter has not been well-studied. We sought to determine the distribution of the largest nerve diameter in ganglionic rectal biopsies and the significance of hypertrophic submucosal nerves in the diagnosis of Hirschsprung disease (HSCR) based on age.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Rectal biopsies performed in the evaluation of HSCR were retrospectively reviewed from 179 patients (151 ganglionic biopsies, 28 aganglionic biopsies), and the diameter of the largest submucosal nerve was measured.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In non-Hirschsprung disease (non-HSCR) biopsies, submucosal nerve diameter increased with age. In patients &lt;1 year, the average diameter was 34.1\u2009\u00b1\u200911.6\u2009\u00b5m but increased to 50.8\u2009\u00b1\u200917.3\u2009\u00b5m after 1 year of age. Submucosal nerves \u226540\u2009\u00b5m in diameter were significantly associated with HSCR across all ages [HSCR\u2009=\u200925\/28 (89.3%) vs non-HSCR\u2009=\u200959\/151 (39.1%), p\u2009&lt;\u20090.0001] and remained significant in patients &lt;1 year of age [HSCR\u2009=\u200922\/24 (91.7%) vs non-HSCR\u2009=\u200919\/91 (20.9%), p\u2009&lt;\u20090.0001].<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The diameter of submucosal nerves increases with age, and \u226540\u2009\u00b5m nerves are common after 1 year of age.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10935266211049689","type":"journal-article","created":{"date-parts":[[2021,11,18]],"date-time":"2021-11-18T07:10:12Z","timestamp":1637219412000},"page":"263-269","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Submucosal Nerve Diameter in the Rectum Increases With Age: An Important Consideration for the Diagnosis of Hirschsprung Disease"],"prefix":"10.1177","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5646-4299","authenticated-orcid":false,"given":"Miriam R","family":"Conces","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Nationwide Children\u2019s Hospital, Columbus, Ohio"},{"name":"Department of Pathology, The Ohio State University College of Medicine, Columbus, 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