{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T20:45:09Z","timestamp":1783975509797,"version":"3.55.0"},"reference-count":15,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2022,5,17]],"date-time":"2022-05-17T00:00:00Z","timestamp":1652745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Pediatr Dev Pathol"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:p>Congenital bile acid synthesis defect type 3 is a rare metabolic liver disease with only eight patients reported in literature. We describe clinical, pathological and molecular features for a ninth patient. A 4-month-old infant presented to us with conjugated hyperbilirubinemia. His liver biopsy revealed giant cell change, steatosis, and activity with diffuse fibrosis. Immunostaining with bile salt export pump showed preserved canalicular pattern and \u03b3-glutamyl transferase 1 staining showed unusual complete membranous pattern. Genetic workup revealed homozygous single base pair duplication in exon 3 of the CYP7B1 gene. He succumbed to liver disease at 7\u00a0months of age.<\/jats:p>","DOI":"10.1177\/10935266221103997","type":"journal-article","created":{"date-parts":[[2022,5,18]],"date-time":"2022-05-18T19:44:31Z","timestamp":1652903071000},"page":"553-557","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Congenital Bile Acid Synthesis Defect Type 3 With Severe Neonatal Cholestasis"],"prefix":"10.1177","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0149-0294","authenticated-orcid":false,"given":"Mukul","family":"Vij","sequence":"first","affiliation":[{"name":"Dr Rela Institute and Medical Centre, Chennai, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vaibhav S.","family":"Shah","sequence":"additional","affiliation":[{"name":"Gujarat Superspeciality Clinic, Ahmedabad, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,5,17]]},"reference":[{"key":"bibr1-10935266221103997","doi-asserted-by":"publisher","DOI":"10.1016\/j.cld.2018.06.006"},{"key":"bibr2-10935266221103997","doi-asserted-by":"publisher","DOI":"10.1016\/j.hbpd.2019.09.003"},{"key":"bibr3-10935266221103997","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-010-9259-3"},{"key":"bibr4-10935266221103997","doi-asserted-by":"publisher","DOI":"10.1038\/ncpgasthep1179"},{"key":"bibr5-10935266221103997","doi-asserted-by":"publisher","DOI":"10.1172\/JCI2962"},{"key":"bibr6-10935266221103997","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e31815a9911"},{"key":"bibr7-10935266221103997","doi-asserted-by":"publisher","DOI":"10.1002\/lt.22331"},{"key":"bibr8-10935266221103997","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-014-9695-6"},{"key":"bibr9-10935266221103997","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2018.33.e324"},{"key":"bibr10-10935266221103997","doi-asserted-by":"publisher","DOI":"10.1016\/j.pedneo.2019.06.009"},{"key":"bibr11-10935266221103997","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-021-01749-x"},{"key":"bibr12-10935266221103997","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2020.00149"},{"key":"bibr13-10935266221103997","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2007.10.001"},{"key":"bibr14-10935266221103997","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R109.042168"},{"key":"bibr15-10935266221103997","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-014-7253-7"}],"container-title":["Pediatric and Developmental Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10935266221103997","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10935266221103997","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10935266221103997","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T04:08:58Z","timestamp":1777694938000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10935266221103997"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,17]]},"references-count":15,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["10.1177\/10935266221103997"],"URL":"https:\/\/doi.org\/10.1177\/10935266221103997","relation":{},"ISSN":["1093-5266","1615-5742"],"issn-type":[{"value":"1093-5266","type":"print"},{"value":"1615-5742","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,17]]}}}