{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:53:18Z","timestamp":1787503998616,"version":"build-2736575974"},"reference-count":17,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2022,12,14]],"date-time":"2022-12-14T00:00:00Z","timestamp":1670976000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Pediatr Dev Pathol"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Acute interstitial nephritis (AIN) is an infrequent cause of acute kidney injury in the pediatric population with a broad range of etiologies. This retrospective review attempts to characterize AIN in the pediatric population, delineate etiologic factors, histologic features, and clinical outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>Institutional pathology reports were queried for a diagnosis of AIN between 1\/2010 and 10\/2021. Archived slides and reports and clinical records were reviewed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Twenty-four patients were identified whose ages ranged from 5 to 20\u2009years. A 8 cases (37.5%) were characterized as tubulointerstitial nephritis and uveitis (TINU), 4 cases (16.7%) were associated with an autoimmune disease, 4 cases (16.7%) were likely drug induced, and 8 cases (37.5%) had unclear etiology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion:<\/jats:title>\n                    <jats:p>Although all cases of drug induced interstitial nephritis contained eosinophils they were not exclusive to drug induced interstitial nephritis. A prominent plasma cell infiltrate was seen in both cases of Sj\u00f6gren\u2019s associated interstitial nephritis. The vast majority (n\u2009=\u200918, 75%) showed an improved serum creatinine (&lt;1\u2009mg\/dL) 1\u2009year post diagnosis\/at last follow-up. In this pediatric series of AIN, TINU contributed to a large subset of cases with known etiologies. On follow up, majority of the cases demonstrated recovery of renal function.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10935266221139663","type":"journal-article","created":{"date-parts":[[2022,12,14]],"date-time":"2022-12-14T07:31:58Z","timestamp":1671003118000},"page":"13-17","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Acute Interstitial Nephritis in the Pediatric Population: A Review of Etiologic Associations, Histologic Findings, and Clinical Outcome"],"prefix":"10.1177","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8877-7281","authenticated-orcid":false,"given":"Laura E.","family":"Biederman","sequence":"first","affiliation":[{"name":"Nationwide Children\u2019s Hospital Department of Pathology, Columbus, OH, USA"},{"name":"Ohio State Wexner Medical Center Department of Pathology, Columbus, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5646-4299","authenticated-orcid":false,"given":"Miriam","family":"Conces","sequence":"additional","affiliation":[{"name":"Nationwide Children\u2019s Hospital Department of Pathology, Columbus, OH, USA"},{"name":"Ohio State Wexner Medical Center Department of Pathology, Columbus, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0733-5260","authenticated-orcid":false,"given":"Archana","family":"Shenoy","sequence":"additional","affiliation":[{"name":"Nationwide Children\u2019s Hospital Department of Pathology, Columbus, OH, USA"},{"name":"Ohio State Wexner Medical Center Department of Pathology, Columbus, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,12,14]]},"reference":[{"key":"bibr1-10935266221139663","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-011-1915-9"},{"key":"bibr2-10935266221139663","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2010.89"},{"key":"bibr3-10935266221139663","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcped.2019.05.002"},{"key":"bibr4-10935266221139663","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-016-3374-9"},{"key":"bibr5-10935266221139663","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-020-1681-7"},{"key":"bibr6-10935266221139663","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6257(01)00261-2"},{"key":"bibr7-10935266221139663","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2012.12.039"},{"key":"bibr8-10935266221139663","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(89)80146-5"},{"key":"bibr9-10935266221139663","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-017-0794-0"},{"key":"bibr10-10935266221139663","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1987.164"},{"key":"bibr11-10935266221139663","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198809223191206"},{"key":"bibr12-10935266221139663","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2004.12.005"},{"key":"bibr13-10935266221139663","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198403013100905"},{"key":"bibr14-10935266221139663","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2012.11.069"},{"key":"bibr15-10935266221139663","doi-asserted-by":"publisher","DOI":"10.1084\/jem.3.4-5.393"},{"key":"bibr16-10935266221139663","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2014.04.027"},{"key":"bibr17-10935266221139663","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-021-05060-5"}],"container-title":["Pediatric and Developmental Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10935266221139663","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10935266221139663","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10935266221139663","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T04:09:21Z","timestamp":1777694961000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10935266221139663"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,14]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["10.1177\/10935266221139663"],"URL":"https:\/\/doi.org\/10.1177\/10935266221139663","relation":{},"ISSN":["1093-5266","1615-5742"],"issn-type":[{"value":"1093-5266","type":"print"},{"value":"1615-5742","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,14]]}}}