{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T23:32:52Z","timestamp":1777937572408,"version":"3.51.4"},"reference-count":39,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2023,2,27]],"date-time":"2023-02-27T00:00:00Z","timestamp":1677456000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Pediatr Dev Pathol"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose and Context:<\/jats:title>\n                    <jats:p>Proximal levels of excised remnants from youngest infants may reveal early features of biliary atresia (BA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method:<\/jats:title>\n                    <jats:p>A targeted IHC survey was applied to 34 most proximal 2 levels in 17 BA remnants excised at age 10\u201374\u2009days including 7\u2009=\u2009&lt;30\u2009days old and 6 control hepatic ducts (HD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key Results:<\/jats:title>\n                    <jats:p>Severity of inflammation and extent of active fibroplasia do not distinguish proximal remnants in younger (n\u2009=\u20097) and older (n\u2009=\u200910) infants. In 27\/34 levels of 14\/17 remnants, reactive stroma is focally SM-MHC-2 (+), marking smooth muscle myosin, termed reactive myogenesis (RM), that is absent in controls. RM facilitates identification of 3 novel hepatic duct remnants (HDR): an HD-like collagen collar lined by degenerating cholangiocytes (n\u2009=\u20095); erosion defects in loose reactive stroma (n\u2009=\u200914); solitary foci of hyperplastic squamoid epithelium (n\u2009=\u20094). Peribiliary glands are either hyperplastic or atretic and typically lack RM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Minimally inflammed end-stage lesions in BA remnants occur at youngest ages favoring prenatal onset. Three novel HDR are defined. RM, a useful surrogate for HDR, is a prevalent inappropriate stromal reaction in proximal remnants of uncertain biological significance. RM is the source of mature smooth muscle in BA remnants.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10935266221146042","type":"journal-article","created":{"date-parts":[[2023,2,27]],"date-time":"2023-02-27T03:04:47Z","timestamp":1677467087000},"page":"259-272","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Biliary Atresia Remnants Revisited: Myogenesis, Hepatic Duct-Like Structures, and Fate of Peribiliary Glands"],"prefix":"10.1177","volume":"26","author":[{"given":"Kevin E.","family":"Bove","sequence":"first","affiliation":[{"name":"Department of Pathology, University of Cincinnati College of Medicine, Cincinnati, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milton J.","family":"Finegold","sequence":"additional","affiliation":[{"name":"Department of Pathology-Immunology, Baylor College of Medicine, Houston, TX, 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