{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T23:34:35Z","timestamp":1777937675242,"version":"3.51.4"},"reference-count":17,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2023,11,30]],"date-time":"2023-11-30T00:00:00Z","timestamp":1701302400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Pediatr Dev Pathol"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:p>B-lymphoblastic leukemia\/lymphoma (B-ALL\/LBL) is a precursor B-cell neoplasm that often harbors specific cytogenetic\/molecular abnormalities with distinctive clinical, phenotypic, and prognostic characteristics. Subcategorization of B-ALL\/LBL therefore requires extensive cytogenetic and\/or molecular testing to determine the appropriate classification and therapeutic interventions for these patients. Herein, we present a case of a 17-year-old young woman diagnosed with B-LBL harboring not only an IGH::MYC rearrangement but also BCL2 and BCL6 rearrangements (so-called \u201ctriple-hit\u201d) and somatic biallelic TP53 inactivation. MYC rearrangements are relatively rare in B-ALL\/LBL, and the identification of a \u201ctriple-hit\u201d elicited an initial diagnostic dilemma. However, a multimodal approach allowed for the classification of this complex case and helped guide selection of an appropriate therapeutic regimen.<\/jats:p>","DOI":"10.1177\/10935266231212337","type":"journal-article","created":{"date-parts":[[2023,11,30]],"date-time":"2023-11-30T12:01:00Z","timestamp":1701345660000},"page":"193-197","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["How Many Tests Does It Take to Diagnose a Triple-Hit B-Lymphoblastic Lymphoma? (Hint, It\u2019s A Lot)"],"prefix":"10.1177","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5484-2639","authenticated-orcid":false,"given":"Marie","family":"Das","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine and Pathology, University of Washington Medical Center, Seattle, WA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen D.","family":"Tsuchiya","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology, University of Washington Medical Center, Seattle, WA, USA"},{"name":"Department of Laboratories, Seattle Children\u2019s Hospital, Seattle, WA, USA"},{"name":"Now at Institute for Genomic Medicine, Nationwide Children\u2019s Hospital, Columbus, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0422-4549","authenticated-orcid":false,"given":"Sandra 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