{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T23:34:39Z","timestamp":1777937679388,"version":"3.51.4"},"reference-count":26,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2024,3,11]],"date-time":"2024-03-11T00:00:00Z","timestamp":1710115200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Pediatr Dev Pathol"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:p>We present 2 diagnostically challenging cases of pediatric\/adolescent relapsed\/refractory aggressive mature B-cell non-Hodgkin lymphoma (B-NHL) within the spectrum of Burkitt lymphoma and diffuse large B-cell lymphoma and illustrate the different therapeutic regimens that are employed for pediatric and adult cancer centers. Both cases displayed varying-sized lymphoma cells with occasional single prominent nucleoli and heterogeneous BCL2 expression. Cytogenetics revealed complex karyotypes with t(8:14)(q24.2;q32) and IGH::MYC rearrangement by FISH. Next generation sequencing revealed deleterious TP53 and MYC mutations. We concluded that both could be diagnosed as \u201cDLBCL-NOS with MYC rearrangement\u201d using the current pathologic classifications, 2022 International Consensus Classification (ICC) and World Health Organization Classifications of Haematolymphoid Tumors (WHO-HAEM5). This report illustrates diagnostic challenges and treatment dilemmas that may be encountered, particularly for adolescent and young adults (AYA).<\/jats:p>","DOI":"10.1177\/10935266241230600","type":"journal-article","created":{"date-parts":[[2024,3,12]],"date-time":"2024-03-12T02:52:50Z","timestamp":1710211970000},"page":"348-353","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Childhood and Adolescent Relapsed\/Refractory Aggressive B-Cell Lymphomas With t(8;14) and BCL2 Expression, Burkitt Lymphoma Versus Diffuse Large B-Cell Lymphoma: A Diagnostic Challenge"],"prefix":"10.1177","volume":"27","author":[{"given":"Fouad","family":"El Dana","sequence":"first","affiliation":[{"name":"Department of Pathology & Immunology, Baylor College of Medicine and Texas Children\u2019s Hospital, Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sofia Alexandra","family":"Garces Narvaez","sequence":"additional","affiliation":[{"name":"Department of Hematopathology, University of Texas MD Anderson Cancer Center, Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nader K.","family":"El-Mallawany","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Section of Hematology-Oncology, Baylor College of Medicine and Texas Children\u2019s Hospital, Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer E.","family":"Agrusa","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Section of Hematology-Oncology, Baylor College of Medicine and Texas Children\u2019s Hospital, Houston, TX, USA"},{"name":"Division of Pediatric Hematology-Oncology, University of Michigan, Ann Arbor, MI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ZoAnn E.","family":"Dreyer","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Section of Hematology-Oncology, Baylor College of Medicine and Texas Children\u2019s Hospital, Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea N.","family":"Marcogliese","sequence":"additional","affiliation":[{"name":"Department of Pathology & Immunology, Baylor College of Medicine and Texas Children\u2019s Hospital, Houston, TX, USA"},{"name":"Department of Pediatrics, Section of Hematology-Oncology, Baylor College of Medicine and Texas Children\u2019s Hospital, Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed Tarek","family":"Elghetany","sequence":"additional","affiliation":[{"name":"Department of Pathology & Immunology, Baylor College of Medicine and Texas Children\u2019s Hospital, Houston, TX, USA"},{"name":"Department of Pediatrics, Section of Hematology-Oncology, Baylor College of Medicine and Texas Children\u2019s Hospital, Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jyotinder N.","family":"Punia","sequence":"additional","affiliation":[{"name":"Department of Pathology & Immunology, Baylor College of Medicine and Texas Children\u2019s Hospital, Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chi Young","family":"Ok","sequence":"additional","affiliation":[{"name":"Department of Hematopathology, University of Texas MD Anderson Cancer Center, Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keyur P.","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Hematopathology, University of Texas MD Anderson Cancer Center, Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dolores H.","family":"Lopez-Terrada","sequence":"additional","affiliation":[{"name":"Department of Pathology & Immunology, Baylor College of Medicine and Texas Children\u2019s Hospital, Houston, TX, 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