{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T23:33:38Z","timestamp":1777937618637,"version":"3.51.4"},"reference-count":28,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2024,6,22]],"date-time":"2024-06-22T00:00:00Z","timestamp":1719014400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"NorthShore University HealthSystem Pilot Award"},{"name":"NorthShore University HealthSystem Auxiliary Research Scholar Award"},{"name":"NorthShore University HealthSystem Career Development Award"},{"name":"Northwestern University Institute for Policy Research"},{"DOI":"10.13039\/100013826","name":"Weinberg College of Arts and Sciences","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100013826","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Pediatr Dev Pathol"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Placental maternal vascular malperfusion (MVM) is characterized by accelerated villous maturation and has been associated with a decrease in the antiaging protein, alpha-klotho (AK). Our aim was to characterize AK protein and gene expression in the placenta and fetal organs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We utilized 2 cohorts. First, we characterized AK protein expression in an autopsy cohort where cases were defined as MVM as the cause of fetal death compared to a stillborn control population. Second, we characterized placental and umbilical cord blood AK gene expression in a liveborn population with and without MVM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>We found decreased protein expression in the villous trophoblastic cells of placentas exposed to severe MVM and decreased AK gene expression in placental tissue exposed to MVM. We did not see any statistically significant differences in fetal organ or umbilical cord blood AK expression based on the presence or absence of MVM. Furthermore, in liveborn infants, we also found increased odds of preterm birth with lower placental AK expression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Decreased AK gene and protein expression in the placenta in the setting of MVM is consistent with the theory of placental aging in MVM and is associated with increased odds of preterm birth.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10935266241259346","type":"journal-article","created":{"date-parts":[[2024,6,22]],"date-time":"2024-06-22T07:35:35Z","timestamp":1719041735000},"page":"559-568","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Decreased Alpha Klotho Expression in Placentas Exposed to Severe Maternal Vascular Malperfusion"],"prefix":"10.1177","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8684-0219","authenticated-orcid":false,"given":"Andrew","family":"Franklin","sequence":"first","affiliation":[{"name":"NorthShore University HealthSystem, Evanston, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9745-7768","authenticated-orcid":false,"given":"Alexa","family":"Freedman","sequence":"additional","affiliation":[{"name":"NorthShore University HealthSystem, Evanston, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann","family":"Borders","sequence":"additional","affiliation":[{"name":"NorthShore University HealthSystem, Evanston, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren","family":"Keenan Devlin","sequence":"additional","affiliation":[{"name":"NorthShore University HealthSystem, Evanston, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erin S.","family":"Proctor","sequence":"additional","affiliation":[{"name":"NorthShore University HealthSystem, Evanston, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erica","family":"Price","sequence":"additional","affiliation":[{"name":"NorthShore University HealthSystem, Evanston, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steve","family":"Cole","sequence":"additional","affiliation":[{"name":"UCLA, Los Angeles, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Greg","family":"Miller","sequence":"additional","affiliation":[{"name":"NorthShore University HealthSystem, Evanston, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0104-5107","authenticated-orcid":false,"given":"Linda M.","family":"Ernst","sequence":"additional","affiliation":[{"name":"NorthShore University HealthSystem, Evanston, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,6,22]]},"reference":[{"key":"bibr1-10935266241259346","doi-asserted-by":"publisher","DOI":"10.1136\/fn.77.3.F171"},{"key":"bibr2-10935266241259346","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-69296-1"},{"key":"bibr3-10935266241259346","doi-asserted-by":"publisher","DOI":"10.1111\/apm.12833"},{"key":"bibr4-10935266241259346","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2019.08.088"},{"key":"bibr5-10935266241259346","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2009.02.005"},{"key":"bibr6-10935266241259346","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2016.09.001"},{"key":"bibr7-10935266241259346","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2017.00323"},{"key":"bibr8-10935266241259346","doi-asserted-by":"publisher","DOI":"10.1111\/aji.12653"},{"key":"bibr9-10935266241259346","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2015-0225-CC"},{"key":"bibr10-10935266241259346","doi-asserted-by":"publisher","DOI":"10.1177\/10935266211008444"},{"key":"bibr11-10935266241259346","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3181e7d975"},{"key":"bibr12-10935266241259346","doi-asserted-by":"publisher","DOI":"10.1038\/36285"},{"key":"bibr13-10935266241259346","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2016.09.010"},{"issue":"3","key":"bibr14-10935266241259346","first-page":"249","volume":"46","author":"Nagai 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