{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T23:33:35Z","timestamp":1777937615931,"version":"3.51.4"},"reference-count":24,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2024,8,31]],"date-time":"2024-08-31T00:00:00Z","timestamp":1725062400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100010249","name":"school of medicine, indiana university","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010249","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Pediatr Dev Pathol"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Invasive fungal intestinal infections are rare in pediatric patients with limited studies reported to date.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Retrospective study of invasive intestinal fungal infections in pediatric patients. For fungal specification, 18S rRNA gene PCR was performed using formalin-fixed paraffin-embedded tissues.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A total of 19 cases from 18 patients were included (13 males, 72%) with a median age of 20\u2009days (8\u2009days\u201314\u2009years). About 13 patients (72%) presented within 67\u2009days of birth and 11 patients (61%) were premature and 14 patients (78%) had a significant medical history. The most common location was the jejunum\/ileum (56%) followed by the right colon and terminal ileum (22%). In 10 patients, the fungal elements were seen in the mucosa with 3 extending into the submucosa, and only 3 patients showed full-thickness involvement. Tissue necrosis and angioinvasion were seen in 13 (72%) and 8 (44%) patients, respectively. Morphologically, organisms consistent with Candida spp. were seen in 17 patients and with a mucoraceous mold in 1 patient. A 18S rRNA gene sequencing performed in 18 cases identified Candida dubliniensis in 16 cases and Candida spp. in 2 cases. During the study follow-up period, 56% of the patients died.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>In our experience, most cases were due to Candida spp. and predominantly in premature infants and associated with poor outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10935266241272564","type":"journal-article","created":{"date-parts":[[2024,8,31]],"date-time":"2024-08-31T03:05:06Z","timestamp":1725073506000},"page":"545-551","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Clinicopathologic Characterization of Invasive Fungal Intestinal Infections in Pediatric Patients"],"prefix":"10.1177","volume":"27","author":[{"given":"Muhammad","family":"Shaheen","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, IN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guang-Sheng","family":"Lei","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, IN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan F.","family":"Relich","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, IN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3383-2212","authenticated-orcid":false,"given":"Iv\u00e1n A.","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, IN, 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