{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T23:33:42Z","timestamp":1777937622928,"version":"3.51.4"},"reference-count":17,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T00:00:00Z","timestamp":1740096000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Pediatr Dev Pathol"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Sloughing esophagitis (esophagitis dissecans superficialis) is a benign, self-limited condition of uncertain etiology. It is most common in adults; pediatric literature is limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Ten years of records were queried for esophageal biopsies containing terms \u201csloughing\u201d and\/or \u201cdissecans.\u201d Histologic inclusion criteria were \u201ctwo-tone\u201d appearance, sloughing\/flaking of superficial epithelium, and parakeratosis. Degree of inflammation was documented and medical records were reviewed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Fourteen patients were identified ranging from 1 to 19\u2009years (mean\u2009=\u200914\u2009years) and included 3 males and 11 females. Two patients were excluded due to lack of histologic criteria\/unavailability of slides for review. Of the 12 cases evaluated, 6 showed a classic inflammation pattern, 5 had minimal or no inflammation, and 1 displayed severe acute inflammation. Endoscopy did not correlate with histology. Sloughing esophagitis is traditionally associated with Selective serotonin reuptake inhibitors (SSRI) use; though 5\/12 patients were taking medication for anxiety or depression, only 3 were taking SSRIs. Five patients had marijuana\/cannabinoid exposure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Sloughing esophagitis can present in the pediatric population across a wide age range. Similar to the adult population, etiology may be linked to medications. Additional associations such as marijuana\/cannabinoid exposure need further clinical investigation. A subset of patients had a history of or subsequently developed eosinophilic esophagitis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10935266251322063","type":"journal-article","created":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T09:38:02Z","timestamp":1740130682000},"page":"172-178","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Sloughing Esophagitis in the Pediatric Age Group: Clinicopathologic Characteristics of 12 Cases"],"prefix":"10.1177","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7696-4525","authenticated-orcid":false,"given":"Ashlie","family":"Rubrecht","sequence":"first","affiliation":[{"name":"Department of Pathology, Immunology, &amp; Lab Medicine, College of Medicine, University of Florida, Gainesville, FL, USA"},{"name":"Department of Pathology, Nationwide Children\u2019s Hospital, Columbus, OH, USA"},{"name":"Department of Pathology, The Ohio State University Wexner Medical Center, Columbus, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Saulino","sequence":"additional","affiliation":[{"name":"Department of Pathology, Immunology, &amp; Lab Medicine, College of Medicine, University of Florida, Gainesville, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elham","family":"Nasri","sequence":"additional","affiliation":[{"name":"Department of Pathology, Immunology, &amp; Lab Medicine, College of Medicine, University of Florida, Gainesville, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6029-0124","authenticated-orcid":false,"given":"Ashwini K.","family":"Esnakula","sequence":"additional","affiliation":[{"name":"Department of Pathology, Immunology, &amp; Lab Medicine, College of Medicine, University of Florida, Gainesville, FL, USA"},{"name":"Department of Pathology, The Ohio State University Wexner Medical Center, Columbus, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David H.","family":"Gonzalo","sequence":"additional","affiliation":[{"name":"Department of Pathology, Immunology, &amp; Lab Medicine, College of Medicine, University of Florida, Gainesville, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael M.","family":"Feely","sequence":"additional","affiliation":[{"name":"Department of Pathology, Immunology, &amp; Lab Medicine, College of Medicine, University of Florida, Gainesville, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Genie L","family":"Beasley","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Florida, Gainesville, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0733-5260","authenticated-orcid":false,"given":"Archana","family":"Shenoy","sequence":"additional","affiliation":[{"name":"Department of Pathology, Immunology, &amp; Lab Medicine, College of Medicine, University of Florida, Gainesville, FL, USA"},{"name":"Department of Pathology, Nationwide Children\u2019s Hospital, Columbus, OH, USA"},{"name":"Department of Pathology, The Ohio State University Wexner Medical Center, Columbus, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,2,21]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.7869\/tg.357"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-015-3590-3"},{"key":"e_1_3_3_4_2","first-page":"753","article-title":"Oesophagitis dissecans superficialis","volume":"3","author":"Rosenberg B.","year":"1892","unstructured":"Rosenberg B. 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