{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T23:34:40Z","timestamp":1777937680508,"version":"3.51.4"},"reference-count":34,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T00:00:00Z","timestamp":1757548800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Pediatr Dev Pathol"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The purpose of this study was to investigate placental pathology and cause of death (COD) in pregnancy losses associated with maternal COVID-19 infection and examine associations with detection of SARS-CoV-2 in placenta and fetal organs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Demographics, placental pathology, and COD information was collected from fetal autopsies done at Evanston hospital, IL between 03\/1\/2020 and 12\/31\/2022 where maternal history indicated positive SARS-CoV-2 test during pregnancy or SARS-CoV-2 infection was suspected after fetal autopsy. Polymerase chain reaction (PCR) testing for SARS-CoV-2 RNA was performed on placenta, fetal liver, and lung tissue.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      We identified 13 autopsies and detected SARS-CoV-2 in placentas of 5 cases, all showed chronic histiocytic intervillositis (CHI) and massive perivillous fibrin deposition (MPVFD). CHI and MPVFD were absent in all the PCR-negative cases (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.001). Fetal liver was positive for SARS-CoV-2 in 1 case, which was in the group with negative placental SARS-CoV-2 PCR. The lung tissue was negative in all cases.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>We confirm the association between detectable placental SARS-CoV-2 with CHI and MPVFD in placentas from pregnancy losses in mother who had COVID-19 during their pregnancy. Detection of SARS-CoV-2 in fetal liver, despite negative placental tissue, was unexpected and may be important for understanding the impact of maternal COVID infection on neonates.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10935266251368434","type":"journal-article","created":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T12:54:58Z","timestamp":1757595298000},"page":"460-468","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Pregnancy Loss Associated with COVID-19 Infection: Associations with Detection of Viral RNA in Placental and Fetal Tissue"],"prefix":"10.1177","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0899-2916","authenticated-orcid":false,"given":"Ansa","family":"Mehreen","sequence":"first","affiliation":[{"name":"Endeavor Health, Department of Pathology and Laboratory Medicine, Evanston, IL, USA"},{"name":"University of Chicago Pritzker School of Medicine, Department of Pathology, Chicago, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-3875-738X","authenticated-orcid":false,"given":"Erica","family":"Price","sequence":"additional","affiliation":[{"name":"Endeavor Health, Department of Pathology and Laboratory Medicine, Evanston, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vivien","family":"Wang","sequence":"additional","affiliation":[{"name":"Endeavor Health, Department of Pathology and Laboratory Medicine, Evanston, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunitha","family":"Suresh","sequence":"additional","affiliation":[{"name":"Endeavor Health, Department of Obstetrics and Gynecology, Evanston, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathy","family":"Mangold","sequence":"additional","affiliation":[{"name":"Endeavor Health, Department of Pathology and Laboratory Medicine, Evanston, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda","family":"Sabatini","sequence":"additional","affiliation":[{"name":"Endeavor Health, Department of Pathology and Laboratory Medicine, Evanston, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Lee","sequence":"additional","affiliation":[{"name":"Endeavor Health, Department of Pathology and Laboratory Medicine, Evanston, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0104-5107","authenticated-orcid":false,"given":"Linda M.","family":"Ernst","sequence":"additional","affiliation":[{"name":"Endeavor Health, Department of Pathology and Laboratory Medicine, Evanston, IL, USA"},{"name":"University of Chicago Pritzker School of Medicine, Department of Pathology, Chicago, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,9,11]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(21)00079-6"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.5001\/omj.2022.52"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2021-0246-SA"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/aqaa089"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2022.03.003"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2022.10.001"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.12522"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2020.30455"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tjog.2022.03.047"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2020.07.049"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.3390\/v14030458"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijscr.2022.107492"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/jog.15302"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/uog.24906"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2015-0225-CC"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1177\/10935266211008444"},{"key":"e_1_3_2_18_2","unstructured":"CDC. 04\/13\/2020: Lab Advisory: Updated Instructions for Use of CDC 2019-nCoV Real-Time RT-PCR Diagnostic Panel (cdc.gov). 2023. 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