{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T23:33:55Z","timestamp":1777937635647,"version":"3.51.4"},"reference-count":39,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T00:00:00Z","timestamp":1761177600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Pediatr Dev Pathol"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Triplet pregnancies have risen in recent decades due to assisted reproductive technology (ART) and are considered high-risk. Placental evaluation is crucial to understanding their outcomes, yet pathological findings in triplet placentas remain poorly described.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>Retrospective observational study including all triplet pregnancies followed at a tertiary referral hospital from January 2000 to December 2024, whose placentas were submitted for pathological analysis. Gross and microscopic findings were reviewed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>We analyzed 111 triplet pregnancies (333 fetuses). Fetal loss (miscarriage or stillbirth) occurred in 7.5%. ART accounted for 70.3% of conceptions. Median gestational age at delivery was 32\u2009weeks (P25\u2009=\u200930; P75\u2009=\u200934), with 50.4% being trichorionic triamniotic. Mean placental weight was 869\u2009\u00b1\u2009243\u2009g, and median size was 22.5\u2009cm (P25\u2009=\u200918; P75\u2009=\u200930). Abnormal umbilical cord insertion was found in 52.2% of cases. Central or peripheral infarcts were present in 43.8% of placentas. The most common histological findings were accelerated villous maturation (65.1%), chorangiosis (53.7%), intervillous fibrin deposits (29.4%), and villous edema (24.3%). Chronic villitis of unknown etiology was the most frequent inflammatory lesion (9.3%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Triplet placentas exhibit high rates of pathological abnormalities, which may contribute to adverse outcomes. Future studies should explore associations with ART and chorionicity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10935266251382963","type":"journal-article","created":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T08:25:17Z","timestamp":1761207917000},"page":"20-26","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Gross and Histopathological Findings of 111 Triplet Placentas: A Descriptive Analysis"],"prefix":"10.1177","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7113-045X","authenticated-orcid":false,"given":"Eva Manuela","family":"Pena-Burgos","sequence":"first","affiliation":[{"name":"Pathology Department, Gregorio Mara\u00f1\u00f3n General University Hospital, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda","family":"De La Calle","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Department, La Paz University Hospital, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose Juan","family":"Pozo-Kreilinger","sequence":"additional","affiliation":[{"name":"Pathology Department, La Paz University Hospital, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rita Mar\u00eda","family":"Regojo-Zapata","sequence":"additional","affiliation":[{"name":"Pathology Department, La Paz University Hospital, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,10,23]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2014.03.001"},{"issue":"2","key":"e_1_3_2_3_2","first-page":"86","article-title":"[Fetal complications and early neonatal outcomes on 147 triplets]","volume":"81","author":"Duyos Mateo I","year":"2013","unstructured":"Duyos Mateo I, de la Calle M, Revello R, Salas P, Zapardiel I, Gonz\u00e1lez A. [Fetal complications and early neonatal outcomes on 147 triplets]. 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Fetomaternal and neonatal outcome of triplet pregnancy. promising results. Saudi Med J. 2011;32(7):685-688.","journal-title":"Saudi Med J"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1017\/thg.2015.94"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.3109\/15513819309048235"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2017.01.029"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1515\/jpm-2020-0141"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.2350\/11-11-1115-OA.1"},{"issue":"6","key":"e_1_3_2_24_2","first-page":"734","article-title":"In vitro fertilization is associated with placental accelerated villous maturation","volume":"14","author":"Londero AP","year":"2021","unstructured":"Londero AP, Orsaria M, Parisi N, et al In vitro fertilization is associated with placental accelerated villous maturation. 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