{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T10:11:36Z","timestamp":1778235096440,"version":"3.51.4"},"reference-count":16,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T00:00:00Z","timestamp":1769731200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Pediatr Dev Pathol"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:p>\n                    Rosai-Dorfman Disease (RDD) is an uncommon histiocytic disorder that can affect lymph nodes and\/or extranodal sites. It is marked by the accumulation of abnormal histiocytes that demonstrate emperipolesis\u2014the active, non-destructive engulfment of other leukocytes. RDD exhibits considerable variability in clinical presentation, pathology, genetics, treatment response, and patient outcomes. In this report, we describe 2 rare cases of RDD that underwent sarcomatous transformation and harbored\n                    <jats:italic toggle=\"yes\">MAP2K1<\/jats:italic>\n                    mutations, both of which demonstrated poor responses to multiple lines of therapy. Additionally, we review 3 other similar cases from the literature.\n                  <\/jats:p>","DOI":"10.1177\/10935266251413973","type":"journal-article","created":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T03:38:08Z","timestamp":1769830688000},"page":"253-258","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Histiocytic Sarcoma Arising From Pediatric Rosai Dorfman Disease: Two Novel Cases and Literature Review"],"prefix":"10.1177","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-5939-4048","authenticated-orcid":false,"given":"Sam","family":"Sirotnikov","sequence":"first","affiliation":[{"name":"Children\u2019s National Hospital, Washington, DC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajeswari","family":"Jayakumar","sequence":"additional","affiliation":[{"name":"Virginia Commonwealth University, Richmond, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunita","family":"Park","sequence":"additional","affiliation":[{"name":"Children\u2019s Healthcare of Atlanta, GA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8930-7903","authenticated-orcid":false,"given":"Jinjun","family":"Cheng","sequence":"additional","affiliation":[{"name":"Mayo Clinic, Phoenix, AZ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,1,30]]},"reference":[{"issue":"1","key":"e_1_3_2_2_2","first-page":"63","article-title":"Sinus histiocytosis with massive lymphadenopathy. A newly recognized benign clinicopathological entity","volume":"87","author":"Rosai J","year":"1969","unstructured":"Rosai J, Dorfman RF. Sinus histiocytosis with massive lymphadenopathy. A newly recognized benign clinicopathological entity. Arch Pathol. 1969;87(1):63-70.","journal-title":"Arch Pathol"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-022-01620-2"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2022015851"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2017.55"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-01-690636"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2019.219626"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2022.4432"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-025-03962-w"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181d5ddf8"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-018-2553-9"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.4103\/ijpm.ijpm_605_22"},{"issue":"4","key":"e_1_3_2_13_2","first-page":"509","article-title":"Sinus histiocytosis with massive lymphadenopathy\u2013a review of seven cases","volume":"49","author":"Agarwal A","year":"2006","unstructured":"Agarwal A, Pathak S, Gujral S. 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