{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T10:11:39Z","timestamp":1778235099657,"version":"3.51.4"},"reference-count":28,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T00:00:00Z","timestamp":1774483200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Pediatr Dev Pathol"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Preterm infants are at risk for white matter brain injury characterized by periventricular leukomalacia (PVL) with exposure to in-utero inflammation. Our aim was to correlate placental pathology with PVL in a cohort of preterm infants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>All infants born &lt;1500\u2009g between Jan 1, 2017 and July 31, 2022 with placental pathology reports and neonatal outcome data on PVL were included in this study. Placental pathology findings were divided into 4 major categories (acute inflammation (AI), chronic inflammation (CI), fetal vascular malperfusion (FVM), and maternal vascular malperfusion (MVM)); each category was graded as absent, low-grade, or high-grade.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      We identified 263 infants with data for PVL and placental pathology. Gestational age (GA) averaged 28 completed weeks and mean birthweight was 1050\u2009g. 11\/263 (4.2%) infants had PVL. Acute inflammation was seen in 9\/11 (82%) infants with PVL and only 101\/252 (40%) of those without PVL (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.01). Eight of the nine infants with PVL and AI (89%) had high-stage AI. In analyses adjusted for gestational age, the prevalences of CI, FVM and MVM were not significantly different between infants with or without PVL.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>In a large cohort of preterm infants, we demonstrate a strong association between AI in the placenta (histologic chorioamnionitis) and PVL in infants born &lt;1500\u2009g.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10935266261427172","type":"journal-article","created":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T05:37:46Z","timestamp":1774589866000},"page":"228-234","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Periventricular Leukomalacia in a Preterm Cohort: Associations With Placental Pathology"],"prefix":"10.1177","volume":"29","author":[{"given":"Soha","family":"Ramadan","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Endeavor Health, Evanston, IL, USA"},{"name":"Department of Pathology, Northwestern University, Chicago, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Franklin","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Neonatology, Endeavor Health, Evanston, IL, USA"},{"name":"Department of Pediatrics, University of Chicago Pritzker School of Medicine, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9745-7768","authenticated-orcid":false,"given":"Alexa","family":"Freedman","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2535-074X","authenticated-orcid":false,"given":"Sunitha","family":"Suresh","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Endeavor Health, Evanston, IL, USA"},{"name":"Department of Obstetrics and Gynecology, University of Chicago Pritzker School of Medicine, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0104-5107","authenticated-orcid":false,"given":"Linda M.","family":"Ernst","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Endeavor Health, Evanston, IL, USA"},{"name":"Department of Pathology, University of Chicago Pritzker School of Medicine, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,3,26]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrdd.20107"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-02-00455.2002"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-010-0411-x"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.714169"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-3782(98)00037-1"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200005183422007"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2007.11.068"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1177\/10935266211008444"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2015-0225-CC"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-196600460-00002"},{"key":"e_1_3_2_12_2","volume-title":"Cerebral Injury New-born Children Consequent on Birth Trauma: With an Inquiry into the Normal and Pathological Anatomy of the Neuroglia","author":"Rydberg E.","year":"1932","unstructured":"Rydberg E. 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