{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T21:26:52Z","timestamp":1793741212183,"version":"4.6.1"},"reference-count":17,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:00:00Z","timestamp":1778716800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100010249","name":"school of medicine, indiana university","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010249","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Pediatr Dev Pathol"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Acute appendicitis is the most common indication for emergent surgery in children and is due to a nonspecific obstruction of the appendiceal lumen. Rare reports have linked the association of adenovirus infection presenting with intussusception with acute appendicitis due to a secondary lymphoid hyperplasia leading to obstruction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>The goal of this study is to evaluate the prevalence of adenovirus infection by immunohistochemistry (IHC) (clone 20\/11 &amp; 2\/6, Cell Marque) in an unbiased cohort of appendectomies due to acute appendicitis in children performed during 1 calendar year.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>421 appendectomies with acute appendicitis (group 1) were included in the study with a median age of 10\u2009years (range: 1-17) and with a male predominance (61%). Additionally, 19 appendectomies performed during an ileocolic intussusception without acute appendicitis (group 2) were included, presenting with a median age of 1\u2009year (range: 3\u2009months-21\u2009years) and a female predominance (63.2%). All group 1 cases showed transmural and periappendiceal acute inflammation, which was absent in all group 2 cases. Adenovirus IHC was negative in all cases in group 1 but positive in 7 cases (36.8%) in group 2. All cases with a positive adenovirus IHC show viral cytopathic changes within the surface epithelium, consistent with adenovirus.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>In this unbiased cohort of pediatric patients with acute appendicitis, adenovirus infection, as detected by IHC, was absent in all cases. Outside the setting of an intussusception and if viral cytopathic changes are not seen on routine histology, adenovirus IHC is not recommended in cases of acute appendicitis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10935266261450264","type":"journal-article","created":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T12:55:16Z","timestamp":1778763316000},"page":"631-634","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["The Role of Adenovirus Immunohistochemistry in Acute Appendicitis in Children"],"prefix":"10.1177","volume":"29","author":[{"given":"Guohua","family":"Liang","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indiana, USA"},{"name":"Department of Pathology, Microbiology &amp; Immunology, Vanderbilt University Medical Center, Nashville, TN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongwei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indiana, USA"},{"name":"Department of Anatomic Pathology, University of Texas MD Anderson Cancer Center, Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3383-2212","authenticated-orcid":false,"given":"Iv\u00e1n A.","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indiana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,5,14]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yapd.2023.03.003"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.8562"},{"issue":"1","key":"e_1_3_3_4_2","first-page":"25","article-title":"Acute appendicitis: efficient diagnosis and management","volume":"98","author":"Snyder MJ","year":"2018","unstructured":"Snyder MJ, Guthrie M, Cagle S. Acute appendicitis: efficient diagnosis and management. Am Fam Physician. 2018;98(1):25-33.","journal-title":"Am Fam Physician"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(15)00275-5"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/s1092-9134(00)90011-x"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-023-04391-z"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bj.2021.08.009"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.3390\/v17070914"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-024-09386-x"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00116-13"},{"issue":"4","key":"e_1_3_3_12_2","first-page":"347","article-title":"Adenovirus and ileocecal intussusception","volume":"33","author":"Yunis EJ","year":"1975","unstructured":"Yunis EJ, Atchison RW, Michaels RH, DeCicco FA. Adenovirus and ileocecal intussusception. Lab Invest. 1975;33(4):347-351.","journal-title":"Lab Invest"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.5306.700"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.2350\/07-06-0299.1"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.7205\/milmed-d-16-00308"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.46.2.154"},{"issue":"2","key":"e_1_3_3_17_2","first-page":"89","article-title":"[Adenovirus and intranuclear inclusions in the appendix in children with acute intussusception]","volume":"17","author":"Berrebi D","year":"1997","unstructured":"Berrebi D, Ferkdadji L, Delagausie P, Aigrain Y, Peuchmaur M. [Adenovirus and intranuclear inclusions in the appendix in children with acute intussusception]. Ann Pathol. 1997;17(2):89-93. Ad\u00e9novirus et inclusions intranucl\u00e9aires dans les appendices au cours des invaginations intestinales aigu\u00ebs de l'enfant.","journal-title":"Ann Pathol"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp-2025-210194"}],"container-title":["Pediatric and Developmental Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10935266261450264","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10935266261450264","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10935266261450264","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T20:28:27Z","timestamp":1793737707000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10935266261450264"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,14]]},"references-count":17,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["10.1177\/10935266261450264"],"URL":"https:\/\/doi.org\/10.1177\/10935266261450264","relation":{},"ISSN":["1093-5266","1615-5742"],"issn-type":[{"value":"1093-5266","type":"print"},{"value":"1615-5742","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,14]]}}}