{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T12:14:17Z","timestamp":1788092057626,"version":"build-2803163510"},"reference-count":18,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:00:00Z","timestamp":1787788800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Shenzhen Science and Technology Program","award":["JCYJ20220530155806014"],"award-info":[{"award-number":["JCYJ20220530155806014"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Pediatr Dev Pathol"],"abstract":"<jats:p>\n                    We describe a 1-year-2-month-old boy with\n                    <jats:italic toggle=\"yes\">KMT2A<\/jats:italic>\n                    -rearranged leukemia presenting with concurrent acute myeloid leukemia in bone marrow and B-lymphoblastic leukemia\/lymphoma in a right calf mass. Both lesions harbored an identical\n                    <jats:italic toggle=\"yes\">KMT2A::MLLT10<\/jats:italic>\n                    fusion, confirming common clonal origin. This represents the first documented case of spontaneous \u201cspatial lineage divergence\u201d at diagnosis, distinct from therapy-induced lineage switch. The finding highlights the potential need for multi-site biopsy and molecular profiling in extramedullary disease.\n                  <\/jats:p>","DOI":"10.1177\/10935266261478989","type":"journal-article","created":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T02:11:43Z","timestamp":1787883103000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Spatial Lineage Divergence at Diagnosis in a Pediatric\n                    <i>KMT2A<\/i>\n                    -Rearranged Leukemia Presenting with Concurrent AML and B-LBL"],"prefix":"10.1177","author":[{"given":"Huan","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Pathology, Shenzhen Children\u2019s Hospital, Shenzhen, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuling","family":"Miao","sequence":"additional","affiliation":[{"name":"Department of Pathology, Shenzhen Children\u2019s Hospital, Shenzhen, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathology, Shenzhen Children\u2019s Hospital, Shenzhen, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pathology, Shenzhen Children\u2019s Hospital, Shenzhen, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Yi","sequence":"additional","affiliation":[{"name":"Department of Hematology\/Oncology, Shenzhen Children\u2019s Hospital, Shenzhen, People\u2019s Republic of 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