{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T22:52:41Z","timestamp":1777935161747,"version":"3.51.4"},"reference-count":19,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T00:00:00Z","timestamp":1771459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"the Project of Wenzhou Science and Technology Bureau","award":["Y2023399"],"award-info":[{"award-number":["Y2023399"]}]},{"name":"the Project of Wenzhou Science and Technology Bureau","award":["Y20240420"],"award-info":[{"award-number":["Y20240420"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Surgical Infections"],"published-print":{"date-parts":[[2026,3,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>We evaluated the early diagnostic value of interleukin-6 (IL-6) for type I and type II necrotizing fasciitis (NF).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A retrospective analysis was conducted of patients with NF between September 2020 and December 2024. They were divided into type I and type II NF. General clinical data, cytokines, and inflammatory markers were compared between the two groups. Threshold cytokine concentrations predictive of type I and type II NF were determined using receiver-operating characteristic (ROC) curve analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A total of 106 patients with NF were included in the study, 74 cases (69.8%) were type I NF, whereas 32 cases (30.2%) were type II. The most commonly identified pathogens associated with type II NF included staphylococcus (n = 16). Cytokine and inflammatory marker analysis of type I NF patients compared with type II NF demonstrated elevated plasma IL-6 concentration in type II NF, and IL-6 remained correlated with type II NF on logistic regression after confounder adjustment (p &lt; 0.05). In addition, ROC analysis revealed plasma IL-6 as a strong type II NF predictor. The area under the curve of plasma IL-6 was 0.94 (95% confidence interval: 0.86\u20131.00, p &lt; 0.05). At the optimal cutoff value of 75.10 pg\/mL, the sensitivity and specificity reached 91% and 100%, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Interleukin-6 can be a supplementary diagnostic marker for early differentiation between type I and type II NF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Trial Registration:<\/jats:title>\n                    <jats:p>KY2022-R142.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10962964251392572","type":"journal-article","created":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T22:42:01Z","timestamp":1761691321000},"page":"138-144","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Interleukin-6 for Early Discrimination Between Type I and Type II Necrotizing Fasciitis"],"prefix":"10.1177","volume":"27","author":[{"given":"Ting-Ting","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Burns, The First Affiliated Hospital Of Wenzhou Medical University, Wenzhou, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoqiong","family":"Jiang","sequence":"additional","affiliation":[{"name":"School of Nursing, Wenzhou Medical University, Wenzhou, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongxin","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Nursing, Wenzhou Medical University, Wenzhou, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zihan","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Nursing, Wenzhou Medical University, Wenzhou, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Medical Engineering, The First Affiliated Hospital Of Wenzhou Medical University, Wenzhou, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiang-Wei","family":"Ling","sequence":"additional","affiliation":[{"name":"Department of Burns, The First Affiliated Hospital Of Wenzhou Medical University, Wenzhou, China."},{"name":"National Key Clinical Specialty (Wound Healing), The First Affiliated Hospital Of Wenzhou Medical University, Wenzhou, China."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,2,19]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0b013e318232a6b3"},{"issue":"4","key":"e_1_3_5_3_2","first-page":"e970","article-title":"Necrotizing fasciitis","volume":"59","author":"Jim\u00e9nez Garc\u00eda Y","year":"2020","unstructured":"Jim\u00e9nez Garc\u00eda Y, , Correa Mart\u00ednez L, , del Carmen Trevin Licea M, et al. Necrotizing fasciitis. Revista Cubana de Cirug\u00eda, 2020; 59(4):e970.","journal-title":"Revista Cubana de Cirug\u00eda"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcjo.2020.10.011"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1089\/sur.2022.317"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12017-023-08762-1"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-025-10691-2"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.5301\/ijao.5000315"},{"issue":"11","key":"e_1_3_5_9_2","first-page":"1465","article-title":"Expert consensus on emergency diagnosis and treatment of necrotizing soft tissue infections","volume":"32","author":"Emergency Physician Branch of Chinese Medical Doctor Association, Chinese Society of Emergency Medicine, First Aid & Resuscitation and Disaster Medicine Committee of Chinese","year":"2023","unstructured":"Emergency Physician Branch of Chinese Medical Doctor Association, Chinese Society of Emergency Medicine, First Aid & Resuscitation and Disaster Medicine Committee of Chinese. Expert consensus on emergency diagnosis and treatment of necrotizing soft tissue infections. Chinese J Emergency Med, 2023; 32(11):1465\u20131475.","journal-title":"Chinese J Emergency Med"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.6846"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.anplas.2022.07.012"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2013.08.012"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2011.04.013"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.7633"},{"issue":"3","key":"e_1_3_5_15_2","first-page":"185","article-title":"IL-6 and IL-10 closely correlate with bacterial blood stream infection","volume":"17","author":"Guan J","year":"2020","unstructured":"Guan J, , Wang Z, , Liu X, et al. IL-6 and IL-10 closely correlate with bacterial blood stream infection. Iran J Immunol, 2020; 17(3):185\u2013203; doi: 10.22034\/iji.2020.87266.1793","journal-title":"Iran J Immunol"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.22692"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2023.04.390"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jot.2019.03.004"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0000000000000988"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1600673"}],"container-title":["Surgical Infections"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10962964251392572","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10962964251392572","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10962964251392572","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T02:47:26Z","timestamp":1777690046000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10962964251392572"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,19]]},"references-count":19,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,3,1]]}},"alternative-id":["10.1177\/10962964251392572"],"URL":"https:\/\/doi.org\/10.1177\/10962964251392572","relation":{},"ISSN":["1096-2964","1557-8674"],"issn-type":[{"value":"1096-2964","type":"print"},{"value":"1557-8674","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,19]]}}}