{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T12:11:38Z","timestamp":1779279098112,"version":"3.51.4"},"reference-count":23,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Surgical Infections"],"published-print":{"date-parts":[[2026,5,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>Occult bacteremia (OB), defined as blood stream micro-organisms confirmed by reverse transcriptase\u2013quantitative polymerase chain reaction that target 16S or 23S ribosomal RNA, has been shown to increase the incidence of post-operative infections during pancreaticoduodenectomy. However, its impact on other surgical procedures remains unclear. This study aimed to evaluate the effect of pre-operative OB on post-operative surgical site infection (SSI) during esophageal cancer surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>In this prospective observational study, 56 patients scheduled for esophagectomy were included. Pre-operative blood samples were tested for OB, and fecal samples were analyzed for microbiota.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Ten patients (18%) exhibited pre-operative OB. These patients had more frequent SSIs than did those without OB (40% vs. 10.9%, p = 0.044). Other complications or clinical factors did not substantially differ between the OB-positive and OB-negative groups. Fecal samples from OB-positive patients presented a greater prevalence of\n                      <jats:italic toggle=\"yes\">Atopobium<\/jats:italic>\n                      clusters. In addition, the same bacterial species were detected in both the blood and feces of five OB-positive patients, with\n                      <jats:italic toggle=\"yes\">Collinsella aerofaciens<\/jats:italic>\n                      being the most commonly shared species among\n                      <jats:italic toggle=\"yes\">Atopobium<\/jats:italic>\n                      clusters.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>\n                      Pre-operative OB increased the risk of SSI following esophagectomy. These findings emphasize the potential role of the gut microbiota, particularly\n                      <jats:italic toggle=\"yes\">Collinsella aerofaciens<\/jats:italic>\n                      , in OB and subsequent infections.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10962964251401456","type":"journal-article","created":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T02:09:41Z","timestamp":1764814181000},"page":"295-303","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of Pre-Operative Occult Bacteremia on Post-Operative Infectious Complications in Patients Undergoing Esophagectomy for Esophageal Cancer"],"prefix":"10.1177","volume":"27","author":[{"given":"Kosuke","family":"Inada","sequence":"first","affiliation":[{"name":"Department of Surgery, Division of Surgical Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukihiro","family":"Yokoyama","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Surgical Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan."},{"name":"Department of Surgery, Division of Perioperative Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazushi","family":"Miyata","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Surgical Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shizuki","family":"Sugita","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Surgical Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuta","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Yakult Central Institute, Yakult Honsha Co., Ltd., Tokyo, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaki","family":"Sunagawa","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Surgical Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan."},{"name":"Department of Surgery, Division of Perioperative Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Ogura","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Surgical Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Asahara","sequence":"additional","affiliation":[{"name":"Yakult Central Institute, Yakult Honsha Co., Ltd., Tokyo, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoki","family":"Ebata","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Surgical Oncology, Nagoya University Graduate School of Medicine, Nagoya, 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