{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,16]],"date-time":"2026-08-16T23:25:55Z","timestamp":1786922755611,"version":"build-2736575974"},"reference-count":34,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T00:00:00Z","timestamp":1775779200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Rare Disease Registration Platform of Shanghai Ninth People's Hospital","award":["JYHJB202405"],"award-info":[{"award-number":["JYHJB202405"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82200621"],"award-info":[{"award-number":["82200621"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Original Exploration Project of Shanghai Ninth People's Hospital","award":["JYYC006"],"award-info":[{"award-number":["JYYC006"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Surgical Infections"],"published-print":{"date-parts":[[2026,10,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Thrombocytopenia is one of the common serious complications among complicated intra-abdominal infection (cIAI) patients. Maximum amplitude (MA), a thromboelastography parameter, represents fibrinogen levels, platelet count, and platelet function. Our study aimed to elucidate the association between decreased MA and mortality among cIAI patients with thrombocytopenia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>cIAI patients with thrombocytopenia were enrolled-in. Clinical data and various laboratory values were collected. Uni-variable analysis and multi-variable logistic regression were used to evaluate the correlation between decreased MA and mortality. The area under the curve (AUC) was calculated to evaluate the predictive performance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A total of 58 cIAI patients with thrombocytopenia were included. According to the uni-variable analysis, decreased MA was significantly associated with patient mortality (odds ratio [OR]: 15.41, 95% confidence interval [CI]: 4.03\u201358.91; p &lt; 0.001). In the multi-variable analysis model 1, which was adjusted for age and gender, decreased MA remained significantly associated with increased patient mortality (OR: 10.96, 95% CI: 2.44\u201349.20; p = 0.002). After adjusting for age, gender, platelet count, acute physiology and chronic health evaluation II score, and sequential organ failure assessment score (model 2), decreased MA was also a risk factor for patient mortality (OR: 12.66, 95% CI: 1.81\u201388.78; p = 0.011). MA levels were significantly lower in non-survivors than in survivors (all p &lt; 0.05). The AUC of MA for predicting mortality was 0.72 (95% CI: 0.58\u20130.87; p = 0.0036).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Decreased MA may be a potential parameter to help predict the likelihood of mortality in cIAI patients with thrombocytopenia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10962964261441210","type":"journal-article","created":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T01:43:04Z","timestamp":1775871784000},"page":"566-571","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Decreased Maximum Amplitude as a Potential Parameter to Predict the Likelihood of Mortality in Complicated Intra-Abdominal Infection Patients with Thrombocytopenia"],"prefix":"10.1177","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5375-9094","authenticated-orcid":false,"given":"Tao","family":"Tian","sequence":"first","affiliation":[{"name":"Department of General Surgery, Shanghai Ninth People\u2019s Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danhua","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Shanghai Ninth People\u2019s Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhua","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Shanghai Ninth People\u2019s Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengfei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Shanghai Ninth People\u2019s Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yousheng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Shanghai Ninth People\u2019s Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,4,10]]},"reference":[{"key":"e_1_3_4_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciae348"},{"key":"e_1_3_4_3_1","doi-asserted-by":"publisher","DOI":"10.1089\/sur.2024.137"},{"key":"e_1_3_4_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/0885066613476465"},{"key":"e_1_3_4_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-200204000-00005"},{"key":"e_1_3_4_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0147482"},{"key":"e_1_3_4_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/2052-0492-1-9"},{"key":"e_1_3_4_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-200006000-00031"},{"key":"e_1_3_4_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/0310057X0703500604"},{"key":"e_1_3_4_10_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.10-2243"},{"key":"e_1_3_4_11_1","doi-asserted-by":"publisher","DOI":"10.1592\/phco.22.11.803.33634"},{"key":"e_1_3_4_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2010.09.002"},{"key":"e_1_3_4_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/1757-7241-21-29"},{"key":"e_1_3_4_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/bf00770880"},{"key":"e_1_3_4_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0000000000000108"},{"key":"e_1_3_4_16_1","volume-title":"StatPearls [Internet].","author":"Kaur J","year":"2019","unstructured":"15.Kaur J, , Jain A. 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