{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T02:39:56Z","timestamp":1792809596566,"version":"4.5.0"},"reference-count":20,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T00:00:00Z","timestamp":1776902400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Surgical Infections"],"published-print":{"date-parts":[[2026,11,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Candidemia is a serious complication after gastrointestinal (GI) perforation and\/or ischemia, yet most evidence pools candidemia with intra-abdominal candidiasis (IAC). We sought candidemia-specific risk factors after GI perforation and\/or ischemia and evaluated associated outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We conducted a single-center, retrospective matched case\u2013control study of adults undergoing emergency surgical procedure for GI perforation and\/or ischemia and admitted to a surgical intensive care unit. Cases with candidemia during index admission were matched 4:1 to controls by age, Charlson Comorbidity Index, and surgical procedure year. Conditional logistic regression assessed pre-specified risk factors, and exploratory outcomes included mortality, length of stay, and days on invasive ventilation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Twenty-four cases were matched to 99 controls. Factors identified to be independently associated with candidemia include the presence of IAC (adjusted OR [aOR]: 5.51, 95% CI: 1.61, 18.89; p = 0.007), upper GI injury (aOR: 4.28, 95% CI: 1.52\u201312.08; p = 0.006), and diffuse intra-abdominal contamination, compared with contained\/none (aOR: 3.21, 95% CI: 1.06\u20139.74; p = 0.040). Among candidemia cases, species distribution was\n                      <jats:italic toggle=\"yes\">Candida albicans<\/jats:italic>\n                      41.7%,\n                      <jats:italic toggle=\"yes\">C. glabrata<\/jats:italic>\n                      33.3%,\n                      <jats:italic toggle=\"yes\">C. parapsilosis<\/jats:italic>\n                      12.5%, with single cases of\n                      <jats:italic toggle=\"yes\">C. tropicalis, C. krusei<\/jats:italic>\n                      , and\n                      <jats:italic toggle=\"yes\">C. dubliniensis<\/jats:italic>\n                      . Candidemia was associated with a longer hospital length of stay (+13.97 d; 95% CI: 0.90\u201327.04; p = 0.036), without significant differences in ICU stay, duration of invasive ventilation, or mortality.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>After GI perforation and\/or ischemia, the risk of candidemia is highest in patients with upper GI injury and diffuse contamination, independent of IAC. These readily identifiable operative features may guide targeted surveillance and selective early antifungal strategies. Prospective validation is warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10962964261445330","type":"journal-article","created":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T01:33:38Z","timestamp":1776994418000},"page":"617-622","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Risk Factors for Developing Candidemia after Gastrointestinal Perforation and\/or Ischemia and Its Outcomes: A Matched Case\u2013Control Study"],"prefix":"10.1177","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3568-0224","authenticated-orcid":false,"given":"Myeongji","family":"Kim","sequence":"first","affiliation":[{"name":"Division of Public Health, Infectious Diseases, and Occupational medicine, Mayo Clinic, Rochester, Minnesota, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nischal","family":"Ranganath","sequence":"additional","affiliation":[{"name":"Division of Public Health, Infectious Diseases, and Occupational medicine, Mayo Clinic, Rochester, Minnesota, USA."},{"name":"Hospital Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia","family":"Molina Garcia","sequence":"additional","affiliation":[{"name":"Division of Public Health, Infectious Diseases, and Occupational medicine, Mayo Clinic, Rochester, Minnesota, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-5655-9737","authenticated-orcid":false,"given":"Kemar O.","family":"Barrett","sequence":"additional","affiliation":[{"name":"Division of Public Health, Infectious Diseases, and Occupational medicine, Mayo Clinic, Rochester, Minnesota, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khalid H.","family":"Mahmoud","sequence":"additional","affiliation":[{"name":"Department of Surgery, Mayo Clinic, Rochester, Minnesota, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan W.","family":"Stevens","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Mayo Clinic, Rochester, Minnesota, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison M.","family":"LeMahieu","sequence":"additional","affiliation":[{"name":"Department of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veljko","family":"Strajina","sequence":"additional","affiliation":[{"name":"Department of Surgery, Mayo Clinic, Rochester, Minnesota, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aditya","family":"Shah","sequence":"additional","affiliation":[{"name":"Division of Public Health, Infectious Diseases, and Occupational medicine, Mayo Clinic, Rochester, Minnesota, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,4,23]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.ss7404a1"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.14744\/nci.2020.27136"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2021.08.081"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40121-021-00585-6"},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000202208.37364.7D"},{"key":"e_1_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(24)00749-7"},{"key":"e_1_3_3_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-005-2794-y"},{"key":"e_1_3_3_9_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.35071"},{"key":"e_1_3_3_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2010.03422.x"},{"key":"e_1_3_3_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-200104000-00010"},{"key":"e_1_3_3_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ccm.0000178352.14703.49"},{"key":"e_1_3_3_13_1","doi-asserted-by":"publisher","DOI":"10.1089\/sur.2023.333"},{"key":"e_1_3_3_14_1","doi-asserted-by":"publisher","DOI":"10.1089\/sur.2023.149"},{"key":"e_1_3_3_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmii.2022.03.001"},{"key":"e_1_3_3_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11695-013-0955-6"},{"key":"e_1_3_3_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/life15060880"},{"key":"e_1_3_3_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/jof11050362"},{"key":"e_1_3_3_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ933"},{"key":"e_1_3_3_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/jof11040258"},{"key":"e_1_3_3_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics15111402"}],"container-title":["Surgical 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