{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T07:38:09Z","timestamp":1787384289464,"version":"build-2736575974"},"reference-count":47,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T00:00:00Z","timestamp":1761609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medicinal Food"],"published-print":{"date-parts":[[2026,7,1]]},"abstract":"<jats:p>\n                    <jats:italic toggle=\"yes\">Pereskia grandifolia<\/jats:italic>\n                    , Cactaceae, is a plant native to temperate and tropical regions. Its leaves and fruits are utilized in food and traditional medicine due to their therapeutic and nutritional properties, which have garnered interest in both pharmaceutical and food industries. This review provides an overview of the current biomedical research on\n                    <jats:italic toggle=\"yes\">P. grandifolia<\/jats:italic>\n                    , encompassing botanical and phytochemical aspects, traditional uses, nutritional evidence,\n                    <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">in\u00a0vivo<\/jats:italic>\n                    preclinical pharmacological studies, and toxicological evaluation. Scientific articles were sourced from databases such as PubMed, Science Direct, SciELO, and Web of Science. Saponins, phenolic compounds, and alkaloids emerge as the main bioactive substances within\n                    <jats:italic toggle=\"yes\">P. grandifolia<\/jats:italic>\n                    . Nutritionally, its leaves and fruits are valued for their high protein and fiber content. In traditional medicine, its leaves are employed to address various ailments, including headache, gastric pain, hemorrhoids, atopic dermatitis, inflammation, hypertension, diabetes, and cancer.\n                    <jats:italic toggle=\"yes\">In vitro<\/jats:italic>\n                    studies on the species have demonstrated antioxidant, cytotoxic, and antimicrobial activity, along with the ability to inhibit the enzyme acetylcholinesterase.\n                    <jats:italic toggle=\"yes\">In vivo<\/jats:italic>\n                    research corroborates its diuretic, antihypertensive, antiobesity, and molluscicidal effects. However, there is limited investigation into its toxicity, and notably, no reports of clinical studies with the species were found. In conclusion, while promising effects of\n                    <jats:italic toggle=\"yes\">P. grandifolia<\/jats:italic>\n                    have been reported, further research is warranted to substantiate its efficacy in folk medicine as an anticancer, antidiabetic, and antihypertensive agent.\n                  <\/jats:p>","DOI":"10.1177\/1096620x251389604","type":"journal-article","created":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T22:37:48Z","timestamp":1761691068000},"page":"428-437","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Exploring the Biomedical Potential of\n                    <i>Pereskia grandifolia<\/i>\n                    : A Comprehensive Review of Botanical, Phytochemical, and Pharmacological Aspects"],"prefix":"10.1177","volume":"29","author":[{"given":"Edilson Rodrigues","family":"Albuquerque","sequence":"first","affiliation":[{"name":"Laboratory of Preclinical Research of Natural Products, Post-Graduate Program in Animal Science with Emphasis on Bioactive Products, Universidade Paranaense, Umuarama, Paran\u00e1, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda de Abreu","family":"Braga","sequence":"additional","affiliation":[{"name":"Laboratory of Preclinical Research of Natural Products, Paranaense University\u2014UNIPAR, Umuarama, Paran\u00e1, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glesie Bertuluci","family":"Martins","sequence":"additional","affiliation":[{"name":"Laboratory of Preclinical Research of Natural Products, Paranaense University\u2014UNIPAR, Umuarama, Paran\u00e1, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ester Pelegrini","family":"Silva","sequence":"additional","affiliation":[{"name":"Laboratory of Preclinical Research of Natural Products, Paranaense University\u2014UNIPAR, Umuarama, Paran\u00e1, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karina Sposito","family":"Negrini","sequence":"additional","affiliation":[{"name":"Laboratory of Preclinical Research of Natural Products, Paranaense University\u2014UNIPAR, Umuarama, Paran\u00e1, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camila Maria Escardille","family":"Yoshitani","sequence":"additional","affiliation":[{"name":"Laboratory of Preclinical Research of Natural Products, Paranaense University\u2014UNIPAR, Umuarama, Paran\u00e1, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arianne Jung","family":"Kluck","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Laboratory of Cardiometabolic Pharmacology, Federal University of Paran\u00e1, Curitiba, Paran\u00e1, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas Pires","family":"Garnier","sequence":"additional","affiliation":[{"name":"Department of Genetic, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo\u2014USP, S\u00e3o Paulo, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo Ratti da","family":"Silva","sequence":"additional","affiliation":[{"name":"Laboratory of Preclinical Research of Natural Products, Paranaense University\u2014UNIPAR, Umuarama, Paran\u00e1, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o Tadeu","family":"Ribeiro-Paes","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, S\u00e3o Paulo State University\u2014UNESP, S\u00e3o Paulo, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francislaine Aparecida dos Reis","family":"L\u00edvero","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Laboratory of Cardiometabolic Pharmacology, Federal University of Paran\u00e1, Curitiba, Paran\u00e1, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,10,28]]},"reference":[{"key":"e_1_3_3_2_2","volume-title":"O milagre das plantas","author":"Bruno I","year":"1998","unstructured":"Bruno I, , Naldi NO. 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