{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T22:52:52Z","timestamp":1777935172528,"version":"3.51.4"},"reference-count":28,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T00:00:00Z","timestamp":1767139200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medicinal Food"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>\n                    Osteoarthritis (OA) is a major cause of pain and reduced mobility in older adults, with few effective treatments currently available. This randomized, double-blind, placebo-controlled trial evaluated the efficacy and safety of\n                    <jats:italic toggle=\"yes\">Boswellia serrata<\/jats:italic>\n                    extract (BOSMAX\u00ae), a botanical anti-inflammatory agent, in participants with non\/mild OA. A total of 150 adults aged 40\u201375 were randomized to receive either BOSMAX\u00ae or a placebo daily for 90 days. Primary outcome measures included WOMAC scores, visual analog scale (VAS) for pain, and Lequesne Functional Index; secondary endpoints were SF-36 scores, tumor necrosis factor-alpha (TNF-\u03b1), and high-sensitivity C-reactive protein (hs-CRP). Significant improvements were observed in the BOSMAX\u00ae group compared with the placebo. The mean total Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scores decreased significantly at days 30 (\u22126.28), 60 (\u221215.24), and 90 (\u221224.55;\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; .05). WOMAC sub-scores (pain, stiffness, and function) and VAS pain scores also showed significant reductions at days 60 and 90. Lequesne Index scores improved progressively (\u22121.37, \u22122.93, and \u22124.53 at days 30, 60, and 90, respectively;\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; .05). TNF-\u03b1 and hs-CRP levels decreased significantly (\u2212104.75 ng\/L and \u22125.67 ng\/mL, respectively;\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; .05) at day 90. However, no significant changes were observed in SF-36 scores. Both treatments exhibited good tolerability, with only one mild and unrelated adverse event reported. Vital signs, physical exams, and laboratory parameters remained clinically unchanged. BOSMAX\u00ae significantly improved knee-joint symptoms and inflammatory markers over 90 days in individuals with non\/mild OA, supporting its potential as a safe therapeutic option.\n                  <\/jats:p>","DOI":"10.1177\/1096620x251392467","type":"journal-article","created":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T07:48:20Z","timestamp":1762933700000},"page":"1-12","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Benefits of\n                    <i>Boswellia Serrata<\/i>\n                    (BOSMAX\u00ae) in Early Knee Osteoarthritis: A Randomized, Placebo-Controlled, Double-Blind Study"],"prefix":"10.1177","volume":"29","author":[{"given":"Manju","family":"Jayaram","sequence":"first","affiliation":[{"name":"Department of Orthopedics, Kempegowda Institute of Medical Sciences, Bengaluru, India."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinhak","family":"Kim","sequence":"additional","affiliation":[{"name":"Daehan Chemtech Co., Ltd., Gwacheon-si, South Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kwang-Soo","family":"Baek","sequence":"additional","affiliation":[{"name":"Daehan Chemtech Co., Ltd., Gwacheon-si, South Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyunmook","family":"Jung","sequence":"additional","affiliation":[{"name":"Cosmax Bio Inc., Seongnam-si, South Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaehwan","family":"Kim","sequence":"additional","affiliation":[{"name":"Cosmax Bio Inc., Seongnam-si, South Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priya","family":"M.K.","sequence":"additional","affiliation":[{"name":"Katra Phytochem (India) Private Limited, Bengaluru, India."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chanappa","family":"T.S.","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Kempegowda Institute of Medical Sciences, Bengaluru, India."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shivkumar","family":"H.B.","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Kempegowda Institute of Medical Sciences, Bengaluru, India."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vijendra","family":"Ramaiah","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Kempegowda Institute of Medical Sciences, Bengaluru, India."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priyanka","family":"S.","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Kempegowda Institute of Medical Sciences, Bengaluru, India."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,12,31]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32230-3"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-204763"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rehab.2016.01.006"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2019.06.011"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.22171"},{"issue":"5","key":"e_1_3_3_7_2","first-page":"3","article-title":"Osteoarthritis is a serious disease","volume":"37","author":"Hawker GA","year":"2019","unstructured":"Hawker GA. Osteoarthritis is a serious disease. Clin Exp Rheumatol, 2019; 37(Suppl 120)(5):3\u20136.","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.2165\/11586800-000000000-00000"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-947227"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2014.02.001"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/7381625"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.6338"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.3746\/pnf.2023.28.3.285"},{"issue":"12","key":"e_1_3_3_14_2","first-page":"1833","article-title":"Validation study of WOMAC: A health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or knee","volume":"15","author":"Bellamy N","year":"1988","unstructured":"Bellamy N, , Buchanan WW, , Goldsmith CH, et al. Validation study of WOMAC: A health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or knee. J Rheumatol, 1988; 15(12):1833\u20131840.","journal-title":"J Rheumatol"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1177\/0091270004263995"},{"issue":"4","key":"e_1_3_3_16_2","first-page":"779","article-title":"The algofunctional indices for hip and knee osteoarthritis","volume":"24","author":"Lequesne MG","year":"1997","unstructured":"Lequesne MG. The algofunctional indices for hip and knee osteoarthritis. J Rheumatol, 1997; 24(4):779\u2013781.","journal-title":"J Rheumatol"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-199905001-00003"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2013.1661"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1080\/07315724.2021.2014370"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1078\/094471103321648593"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.4103\/0253-7613.30759"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1186\/ar2461"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-011-0818-1"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1177\/0394632015622215"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.4103\/ijabmr.IJABMR_248_18"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2010.03.003"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.4103\/0250-474X.93507"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1515\/dmpt-2020-0104"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.8.615"}],"container-title":["Journal of Medicinal Food"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1096620X251392467","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1096620X251392467","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1096620X251392467","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T02:48:05Z","timestamp":1777690085000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.1177\/1096620X251392467"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,31]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1177\/1096620X251392467"],"URL":"https:\/\/doi.org\/10.1177\/1096620x251392467","relation":{},"ISSN":["1096-620X","1557-7600"],"issn-type":[{"value":"1096-620X","type":"print"},{"value":"1557-7600","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,31]]}}}