{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T22:46:11Z","timestamp":1782341171696,"version":"3.54.5"},"reference-count":69,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T00:00:00Z","timestamp":1766534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medicinal Food"],"published-print":{"date-parts":[[2026,8,1]]},"abstract":"<jats:p>\n                    Dietary modification in early life can either increase susceptibility or improve resistance to metabolic diseases in adulthood. This study evaluated the potential of lycopene to mitigate metabolic derangements caused by a high-fructose diet in rats mimicking adolescents fed a high-fructose diet. Ninety-six weanling Wistar rats (male and female, aged 21 days) were randomly allocated to six treatment groups: (1) standard rat chow (SRC), plain drinking water (PDW), and plain gelatin cubes (PG); (2) SRC + PDW + 20% fructose solution (FS); (3) SRC + FS + 100 mg\/kg fenofibrate (FENO) + PG; and (4\u20136) SRC + FS with lycopene at 30, 60, and 100 mg\/kg\/day, respectively, for 12 weeks. Body mass, feed, and fluid intake were measured twice weekly. At termination, rats were fasted overnight, weighed, euthanized, and assessed for gastrointestinal viscera, femora, and tibiae parameters, including mass and length, with bone mass-to-length ratios computed. The rats grew significantly (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; .05) during the trial. Control males had higher mean weekly body mass than medium-dose lycopene-supplemented rats (weeks 3\u20134) and fenofibrate-treated rats (weeks 10\u201312), and higher terminal body mass than fructose-fed and fenofibrate groups (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; .05). In both sexes, controls had greater total feed intake (TFI) than all groups (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; .05). Lycopene reduced TFI but increased fluid intake compared with control and fenofibrate-treated groups (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; .05). Fenofibrate increased total calorie intake in females compared with all groups and in males compared with fructose-fed and lycopene-supplemented groups (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; .05). Lycopene-supplemented males had heavier femora and longer tibiae than fenofibrate-treated counterparts (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; .05). Medium- and high-dose lycopene increased stomach mass in males compared with controls, while low-dose lycopene reduced small intestine mass compared with fenofibrate (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; .05). Lycopene may support bone health, enhance gastric function, and prevent fenofibrate-induced bone loss in male Wistar rats.\n                  <\/jats:p>","DOI":"10.1177\/1096620x251409053","type":"journal-article","created":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T16:52:54Z","timestamp":1768063974000},"page":"471-484","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Supplemental Lycopene Reduces Feed Intake, Increases Fluid Consumption, and Enhances Bone and Stomach Growth in Growing Wistar Rats Fed a High-Fructose Diet"],"prefix":"10.1177","volume":"29","author":[{"given":"Mercy Omoye","family":"Shafe","sequence":"first","affiliation":[{"name":"School of Biomedical Sciences, Department of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa."},{"name":"Department of Human Physiology, Faculty of Basic Medical Sciences, College of Medicine and Allied Health Sciences, Bingham University, Nasarawa, Nigeria."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nontobeko Myllet","family":"Gumede","sequence":"additional","affiliation":[{"name":"Department of Physiology, School of Medicine, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trevor Tapiwa","family":"Nyakudya","sequence":"additional","affiliation":[{"name":"Department of Physiology, School of Medicine, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliton","family":"Chivandi","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences, Department of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,12,24]]},"reference":[{"key":"e_1_3_4_2_1","doi-asserted-by":"publisher","DOI":"10.1055\/S-0038-1660790"},{"key":"e_1_3_4_3_1","doi-asserted-by":"publisher","DOI":"10.21037\/tp.2017.10.02"},{"key":"e_1_3_4_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/metabo13060716"},{"key":"e_1_3_4_5_1","doi-asserted-by":"publisher","DOI":"10.1101\/669804"},{"key":"e_1_3_4_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/and.13730"},{"key":"e_1_3_4_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12051536"},{"key":"e_1_3_4_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13098-022-00800-5"},{"key":"e_1_3_4_9_1","doi-asserted-by":"publisher","DOI":"10.21315\/mjms2017.24.5.11"},{"key":"e_1_3_4_10_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00446.2012"},{"issue":"6","key":"e_1_3_4_11_1","first-page":"854","article-title":"Survey of osteoporosis risk factors","volume":"25","author":"Askari M","year":"2019","unstructured":"Askari M, , Lotfi MH, , Owlia MB et al. 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