{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T22:53:03Z","timestamp":1777935183719,"version":"3.51.4"},"reference-count":34,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T00:00:00Z","timestamp":1767916800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medicinal Food"],"published-print":{"date-parts":[[2026,2,1]]},"abstract":"<jats:p>\n                    This study aimed to evaluate the effects of low-lactose processed milk consumption on body composition, clinical indicators, hydrogen breath levels, and gut microbiome changes in Korean adults with lactose intolerance. A total of 32 participants diagnosed with lactose intolerance, as determined by a hydrogen breath test, were enrolled in the study. During the 30-day intervention period, participants consumed one serving per day of banana-flavored milk containing 10.2 g of lactose. Stool and breath samples were collected before and after the intervention to assess changes in gut microbiota composition and lactose malabsorption. Following the intervention, significant improvements were observed in body composition, including reductions in body fat percentage (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; .001) and increases in fat-free mass (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; .001), skeletal muscle mass (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; .001), and soft-tissue lean mass (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; .001). Blood pressure also decreased; however, no significant changes were observed in hematological markers. Hydrogen breath test results demonstrated a significant reduction in hydrogen breath levels, and 40.6% of participants were reclassified as negative for lactose intolerance post-intervention. While no significant changes were observed in alpha diversity or overall microbial composition across all participants, a significant increase in the relative abundance of the\n                    <jats:italic toggle=\"yes\">Weissella confusa group<\/jats:italic>\n                    (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = .007) was detected in individuals who tested negative for lactose intolerance after consuming the intervention food. These findings suggest that consuming low-lactose processed milk improves lactose intolerance, body composition, and gut microbiota composition, providing a feasible dietary strategy for managing lactose intolerance in adults.\n                  <\/jats:p>","DOI":"10.1177\/1096620x251412892","type":"journal-article","created":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T12:56:22Z","timestamp":1767963382000},"page":"61-70","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of Low-Lactose Processed Milk on Clinical Symptoms and Gut Microbiome Modulation in Lactose-Intolerant Adults"],"prefix":"10.1177","volume":"29","author":[{"given":"Dong Hoon","family":"Jung","sequence":"first","affiliation":[{"name":"Department of Gerontology, Age Tech-Service Convergence Major, Graduate School of East-West Medical Science, Kyung Hee University, Yongin, Republic of Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji-Min","family":"Cha","sequence":"additional","affiliation":[{"name":"Department of Gerontology, Age Tech-Service Convergence Major, Graduate School of East-West Medical Science, Kyung Hee University, Yongin, Republic of Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ha-neul","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Gerontology, Age Tech-Service Convergence Major, Graduate School of East-West Medical Science, Kyung Hee University, Yongin, Republic of Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ye-Rin","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Gerontology, Age Tech-Service Convergence Major, Graduate School of East-West Medical Science, Kyung Hee University, Yongin, Republic of Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gi Moon","family":"Nam","sequence":"additional","affiliation":[{"name":"Department of Gerontology, Age Tech-Service Convergence Major, Graduate School of East-West Medical Science, Kyung Hee University, Yongin, Republic of Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang Kyun","family":"Lee","sequence":"additional","affiliation":[{"name":"Center for Crohn\u2019s and Colitis, Department of Gastroenterology, Kyung Hee University College of Medicine, Seoul, Republic of Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chul-Hong","family":"Kim","sequence":"additional","affiliation":[{"name":"Food Research Center, Binggrae Co., Ltd, Namyangju, Republic of Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyun-San","family":"Lim","sequence":"additional","affiliation":[{"name":"Food Research Center, Binggrae Co., Ltd, Namyangju, Republic of Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji Yeon","family":"Lee","sequence":"additional","affiliation":[{"name":"Food Research Center, Binggrae Co., Ltd, Namyangju, Republic of Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hee-Sook","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Gerontology, Age Tech-Service Convergence Major, Graduate School of East-West Medical Science, Kyung Hee University, Yongin, Republic of Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,1,9]]},"reference":[{"key":"e_1_3_5_2_2","unstructured":"World Population Review. Lactose intolerance by country 2024. Available from: https:\/\/worldpopulationreview.com\/country-rankings\/lactose-intolerance-by-country [Last accessed: January20 2025]."},{"key":"e_1_3_5_3_2","first-page":"643","article-title":"A study of lactose intolerance using breath hydrogen test in Korean healthy adults","volume":"30","author":"Chang YW","year":"1986","unstructured":"Chang YW, , Park CG, , Bang IS, et al. A study of lactose intolerance using breath hydrogen test in Korean healthy adults. Korean J Med, 1986; 30:643\u2013648.","journal-title":"Korean J Med"},{"issue":"9","key":"e_1_3_5_4_2","first-page":"1845","article-title":"Lactose intolerance","volume":"65","author":"Swagerty DL","year":"2002","unstructured":"Swagerty DLJr, , Walling AD, , Klein RM. Lactose intolerance. 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