{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T00:32:38Z","timestamp":1793838758214,"version":"4.6.1"},"reference-count":35,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:00:00Z","timestamp":1773014400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"The Food Industry Promotional Agency"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medicinal Food"],"published-print":{"date-parts":[[2026,5,1]]},"abstract":"<jats:p>\n                    Muscle atrophy, characterized by a decline in muscle mass and function, results from an imbalance between protein synthesis and degradation. This study explored the effects of standardized\n                    <jats:italic toggle=\"yes\">Lespedeza cuneata<\/jats:italic>\n                    extract (LCE) on dexamethasone (DEX)-induced muscle atrophy. The mice were orally administered LCE for 17 days. Starting on day 7 of oral administration, DEX was intraperitoneally injected into mice daily for 10 days to induce muscle atrophy. LCE treatment significantly improved grip strength by 22.27% and 33.16% and increased muscle volume by 17.47% and 23.00% at doses of 250 and 500 mg\/kg\/day, respectively, compared with the DEX group, and also markedly restored hind limb muscle weight. At the molecular level, LCE decreased the mRNA expression of myostatin, muscle ring finger1, and muscle atrophy F-box, which are involved in proteolysis, by inhibiting forkhead box O3a translocation. Furthermore, LCE activated the mammalian target of rapamycin pathway and upregulated myogenesis-related genes via the phosphoinositide 3-kinase\/Akt pathway. It also reduced nuclear factor kappa B-mediated inflammatory cytokines, including tumor necrosis factor alpha and interleukin-6. Thus, LCE may serve as a functional food ingredient that prevents muscle atrophy.\n                  <\/jats:p>","DOI":"10.1177\/1096620x261428023","type":"journal-article","created":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T11:03:01Z","timestamp":1773226981000},"page":"247-256","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Preventive Effect of Standardized\n                    <i>Lespedeza cuneata<\/i>\n                    Extract on Dexamethasone-Induced Muscle Atrophy in C57BL\/6N Mice"],"prefix":"10.1177","volume":"29","author":[{"given":"Minseong","family":"Kang","sequence":"first","affiliation":[{"name":"Graduate Program in Bioindustrial Engineering, Yonsei University, Seoul, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Jin","family":"Kim","sequence":"additional","affiliation":[{"name":"R&amp;D Center, Naturalway Co. 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