{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:40:28Z","timestamp":1777945228485,"version":"3.51.4"},"reference-count":38,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T00:00:00Z","timestamp":1776384000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medicinal Food"],"published-print":{"date-parts":[[2026,5,1]]},"abstract":"<jats:p>\n                    Osteoarthritis (OA) is characterized by inflammation-driven chondrocyte senescence and extracellular-matrix degradation. However, the molecular mechanisms linking inflammatory stress to chondrocyte aging remain poorly understood. Here, we identify cinnamyl alcohol (CA) as a natural small-molecule compound that attenuates OA progression through polymeric immunoglobulin receptor (PIGR)-mediated signaling\n                    <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                    . CA reduced inflammatory cytokine production, suppressed senescence-associated secretory phenotype gene expression, and preserved cartilage homeostasis in lipopolysaccharide- or interleukin-1\u03b2-stimulated chondrocytes. In a destabilization-of-the-medial-meniscus mouse model, intra-articular CA administration markedly alleviated cartilage degeneration and matrix loss. Integrating network pharmacology, molecular docking, and mass-spectrometry-based proteomic profiling, we identified PIGR as a convergent target of CA, validated by limited proteolysis (drug affinity responsive target stability) and loss-of-function assays. PIGR silencing abolished CA\u2019s antisenescent and cartilage-protective effects, confirming its essential role. Mechanistically, CA restored PIGR expression to modulate inflammatory signaling and maintain chondrocyte phenotype stability. These findings uncover a previously unrecognized CA\u2013PIGR axis that couples inflammatory stress to cartilage aging and suggest CA as a promising natural therapeutic candidate for OA management.\n                  <\/jats:p>","DOI":"10.1177\/1096620x261430173","type":"journal-article","created":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T15:21:11Z","timestamp":1776439271000},"page":"279-293","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Cinnamyl Alcohol Attenuates Osteoarthritis Progression via PIGR-Mediated Regulation of Chondrocyte Senescence and Cartilage Homeostasis"],"prefix":"10.1177","volume":"29","author":[{"given":"Qi","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine, The First Affiliated Hospital of Army Medical University of the People\u2019s Liberation Army of China, Chongqing, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingxia","family":"You","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, The First Affiliated Hospital of Army Medical University of the People\u2019s Liberation Army of China, Chongqing, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaojiao","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, The First Affiliated Hospital of Army Medical University of the People\u2019s Liberation Army of China, Chongqing, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongting","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, The First Affiliated Hospital of Army Medical University of the People\u2019s Liberation Army of China, Chongqing, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuhan","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, The First Affiliated Hospital of Army Medical University of the People\u2019s Liberation Army of China, Chongqing, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanmeng","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, The First Affiliated Hospital of Army Medical University of the People\u2019s Liberation Army of China, Chongqing, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Miao","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, The First Affiliated Hospital of Army Medical University of the People\u2019s Liberation Army of China, Chongqing, China."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,4,17]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01330-w"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/bor.0000000000000985"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2023.11.015"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.907750"},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2023.11.018"},{"key":"e_1_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-020-00533-7"},{"key":"e_1_3_3_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard-2022-223227"},{"key":"e_1_3_3_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-024-00727-x"},{"key":"e_1_3_3_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2016.65"},{"key":"e_1_3_3_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2019.101306"},{"key":"e_1_3_3_12_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.85585"},{"key":"e_1_3_3_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-35424-w"},{"key":"e_1_3_3_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/10717544.2021.1971798"},{"key":"e_1_3_3_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-022-00879-w"},{"key":"e_1_3_3_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.891822"},{"key":"e_1_3_3_17_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm-21-6130"},{"key":"e_1_3_3_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.1c00272"},{"key":"e_1_3_3_19_1","doi-asserted-by":"publisher","DOI":"10.3858\/emm.2012.44.12.083"},{"key":"e_1_3_3_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2010.196"},{"key":"e_1_3_3_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2015.07.011"},{"key":"e_1_3_3_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2007.03.006"},{"key":"e_1_3_3_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.118"},{"key":"e_1_3_3_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.00123"},{"key":"e_1_3_3_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2024.105344"},{"key":"e_1_3_3_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2011.37"},{"key":"e_1_3_3_27_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.167.11.6412"},{"key":"e_1_3_3_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-20811-6"},{"key":"e_1_3_3_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eng.2024.01.006"},{"key":"e_1_3_3_30_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2021-221380"},{"key":"e_1_3_3_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2010.05.025"},{"key":"e_1_3_3_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-2269-7_22"},{"key":"e_1_3_3_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2015.10.036"},{"key":"e_1_3_3_34_1","doi-asserted-by":"publisher","DOI":"10.1080\/08820139.2023.2280248"},{"key":"e_1_3_3_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2020.02.027"},{"key":"e_1_3_3_36_1","doi-asserted-by":"publisher","DOI":"10.1080\/13880209.2019.1651874"},{"key":"e_1_3_3_37_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00553"},{"key":"e_1_3_3_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kex417"},{"key":"e_1_3_3_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-020-00670-x"}],"container-title":["Journal of Medicinal Food"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1096620X261430173","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1096620X261430173","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1096620X261430173","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T10:18:31Z","timestamp":1777717111000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1096620X261430173"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,17]]},"references-count":38,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5,1]]}},"alternative-id":["10.1177\/1096620X261430173"],"URL":"https:\/\/doi.org\/10.1177\/1096620x261430173","relation":{},"ISSN":["1096-620X","1557-7600"],"issn-type":[{"value":"1096-620X","type":"print"},{"value":"1557-7600","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,17]]}}}