{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T20:30:39Z","timestamp":1788813039329,"version":"build-2803163510"},"reference-count":46,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T00:00:00Z","timestamp":1774224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"hy Co., Ltd.","award":["2025-0062"],"award-info":[{"award-number":["2025-0062"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medicinal Food"],"published-print":{"date-parts":[[2026,6,1]]},"abstract":"<jats:p>\n                    <jats:italic toggle=\"yes\">Helicobacter pylori<\/jats:italic>\n                    (\n                    <jats:italic toggle=\"yes\">H. pylori<\/jats:italic>\n                    ) is a major pathogen that colonizes the human gastric surface and induces chronic inflammation and mucosal damage, leading to various gastric diseases. This study examined the gastroprotective effects of\n                    <jats:italic toggle=\"yes\">Lacticaseibacillus paracasei<\/jats:italic>\n                    HP7 in an\n                    <jats:italic toggle=\"yes\">H. pylori<\/jats:italic>\n                    -infected animal model. Male C57BL\/6 mice were divided into four groups: normal control,\n                    <jats:italic toggle=\"yes\">H. pylori<\/jats:italic>\n                    -infected control (HP),\n                    <jats:italic toggle=\"yes\">H. pylori<\/jats:italic>\n                    -infected group treated with live\n                    <jats:italic toggle=\"yes\">L. paracasei<\/jats:italic>\n                    HP7 for 4 weeks (L-HP7), and\n                    <jats:italic toggle=\"yes\">H. pylori<\/jats:italic>\n                    -infected group treated with heat-killed\n                    <jats:italic toggle=\"yes\">L. paracasei<\/jats:italic>\n                    HP7 for 4 weeks (HK-HP7). The results showed that serum histamine and gastrin levels, as well as gastric mucosal inflammatory cytokine mRNA levels, including interleukin (IL)-1\u03b2, IL-6, IL-8, IL-18, interferon gamma, and tumor necrosis factor alpha, were significantly reduced in both the L-HP7 and HK-HP7 groups. Histopathological scoring of hematoxylin &amp; eosin-stained gastric mucosal tissues also showed significant improvements in both groups. Serum anti-\n                    <jats:italic toggle=\"yes\">H. pylori<\/jats:italic>\n                    immunoglobulin G (IgG) and CCK2R mRNA levels decreased in the L-HP7 group, whereas MUC1 mRNA levels increased. Collectively, these findings indicate that\n                    <jats:italic toggle=\"yes\">L. paracasei<\/jats:italic>\n                    HP7, in both live and heat-killed forms, protects gastric surface epithelial and mucosal cells and alleviates inflammatory status by reducing the expression of pro-inflammatory cytokines.\n                    <jats:italic toggle=\"yes\">L. paracasei<\/jats:italic>\n                    HP7 may serve as a promising adjunct to antibiotics in the management of\n                    <jats:italic toggle=\"yes\">H. pylori<\/jats:italic>\n                    -associated diseases.\n                  <\/jats:p>","DOI":"10.1177\/1096620x261435979","type":"journal-article","created":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T13:21:45Z","timestamp":1774272105000},"page":"332-341","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Effects of\n                    <i>Lacticaseibacillus paracasei<\/i>\n                    HP7 Against\n                    <i>Helicobacter pylori<\/i>\n                    -Induced Gastric Mucosal Inflammation and Mucosal Protection"],"prefix":"10.1177","volume":"29","author":[{"given":"Heewoo","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Food and Nutrition, The University of Suwon, Hwaseong, South Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7803-3740","authenticated-orcid":false,"given":"Jeong Yoon","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Food and Nutrition, The University of Suwon, Hwaseong, South Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae-Ho","family":"Lee","sequence":"additional","affiliation":[{"name":"R&amp;BD Center, hy Co., Ltd., Yongin-si, South Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ju-Yeon","family":"Kim","sequence":"additional","affiliation":[{"name":"R&amp;BD Center, hy Co., Ltd., Yongin-si, South Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Il-Dong","family":"Choi","sequence":"additional","affiliation":[{"name":"R&amp;BD Center, hy Co., Ltd., Yongin-si, South Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae-Jung","family":"Shim","sequence":"additional","affiliation":[{"name":"R&amp;BD Center, hy Co., Ltd., Yongin-si, South Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae-Hwan","family":"Lee","sequence":"additional","affiliation":[{"name":"R&amp;BD Center, hy Co., Ltd., Yongin-si, South Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoo-Hyun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Food and Nutrition, The University of Suwon, Hwaseong, South 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