{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:08:18Z","timestamp":1788998898527,"version":"build-2803163510"},"reference-count":46,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:00:00Z","timestamp":1777420800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"crossref","award":["2022\/03712-0"],"award-info":[{"award-number":["2022\/03712-0"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medicinal Food"],"published-print":{"date-parts":[[2026,10,1]]},"abstract":"<jats:p>\n                    Chronic kidney disease (CKD) is a systemic condition associated with inflammation and oxidative stress, affecting organs beyond the kidneys. Although rarely emphasized, the eyes may also be affected but underlying molecular mechanisms remain largely unexplored. The gut\u2013kidney and gut\u2013eye axes are emerging as therapeutic targets with prebiotics like ResistAid\u00ae-a Larch Arabinogalactan (LAG) supplement with antioxidant and immunomodulatory effects\u2014showing promise through gut microbiota modulation. This study assessed ResistAid\u00ae\u2019s effects on ocular gene expression in a CKD rat model. Twenty four Wistar rats were assigned to Sham (S), Sham + Treatment (ST), Nephrectomized (N), Nephrectomized + Treatment (NT) (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    = 6 each). CKD was induced by 5\/6 nephrectomy. The treatment was administered via gavage for 30 days at a dose of 5.35 mg\/day, adapted from human recommendations. At day 30, blood and tissues were collected. Expression of antioxidant enzymes (\n                    <jats:italic toggle=\"yes\">Cat, Sod1, Gpx1, Gpx4<\/jats:italic>\n                    ) and other genes (\n                    <jats:italic toggle=\"yes\">Nfe2l2, Nf\u03bab1, Timp3, Hif-1\u03b1, Kim1, Klotho<\/jats:italic>\n                    ) was analyzed by qPCR. Biochemical and well-being assessments were also conducted. Nephrectomy, regardless of treatment, increased\n                    <jats:italic toggle=\"yes\">Sod1<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">Hif1\u0251<\/jats:italic>\n                    expression in eye and blood; Specific to NT animals, ocular\n                    <jats:italic toggle=\"yes\">Gpx1<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">Gpx4<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">Nfe2l2<\/jats:italic>\n                    expressions were markedly elevated when compared with N animals and blood\n                    <jats:italic toggle=\"yes\">Kim1<\/jats:italic>\n                    and ocular\n                    <jats:italic toggle=\"yes\">Nf\u03bab1<\/jats:italic>\n                    expressions were not elevated, differing from N animals. No significant changes were observed between the S and ST groups. CKD induces systemic oxidative and inflammatory responses. ResistAid\u00ae partially mitigated these effects in blood and eye, suggesting systemic and local benefits, possibly via gut microbiota modulation.\n                  <\/jats:p>","DOI":"10.1177\/1096620x261447993","type":"journal-article","created":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T12:19:47Z","timestamp":1777465187000},"page":"594-602","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Modulation of Antioxidant and Anti-Inflammatory Response in the Eyes of CKD Animals Supplemented with Larch Arabinogalactan"],"prefix":"10.1177","volume":"29","author":[{"given":"Pedro Henrique","family":"Alves Reis","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio De An\u00e1lises Cl\u00ednicas, Centro Universit\u00e1rio FMABC, Santo Andr\u00e9, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabela de Paula","family":"Destro","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio De An\u00e1lises Cl\u00ednicas, Centro Universit\u00e1rio FMABC, Santo Andr\u00e9, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid Bertollini","family":"Lamy","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio De An\u00e1lises Cl\u00ednicas, Centro Universit\u00e1rio FMABC, Santo Andr\u00e9, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuliana","family":"Petri","sequence":"additional","affiliation":[{"name":"Biot\u00e9rio do Centro Universit\u00e1rio FMABC, Santo Andr\u00e9, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estella Freitas","family":"Silvestri","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio De An\u00e1lises Cl\u00ednicas, Centro Universit\u00e1rio FMABC, Santo Andr\u00e9, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabella Dudjak Rosa","family":"Trufelli","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio De An\u00e1lises Cl\u00ednicas, Centro Universit\u00e1rio FMABC, Santo Andr\u00e9, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz da Costa Aguiar","family":"Alves","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio De An\u00e1lises Cl\u00ednicas, Centro Universit\u00e1rio FMABC, Santo Andr\u00e9, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vagner Loduca","family":"Lima","sequence":"additional","affiliation":[{"name":"Disciplina de Oftalmologia do Centro Universit\u00e1rio FMABC, Santo Andr\u00e9, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glaucia Luciano","family":"da Veiga","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio De An\u00e1lises Cl\u00ednicas, Centro Universit\u00e1rio FMABC, Santo Andr\u00e9, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando Luiz Affonso","family":"Fonseca","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio De An\u00e1lises Cl\u00ednicas, Centro Universit\u00e1rio FMABC, Santo Andr\u00e9, Brazil."},{"name":"Departamento De Ci\u00eancias Farmac\u00eauticas, Universidade Federal de S\u00e3o Paulo, Diadema, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,4,29]]},"reference":[{"key":"e_1_3_3_2_1","unstructured":"1.Brasil. Minist\u00e9rio da Sa\u00fade Secretaria de Vigil\u00e2ncia em Sa\u00fade Servi\u00e7o de Informa\u00e7\u00f5es sobre Mortalidade (SIM). \u00d3bitos por ocorr\u00eancia segundo cap\u00edtulo CID-10 2019. Bras\u00edlia: Minist\u00e9rio da Sa\u00fade; 2019. Dispon\u00edvel em. Available from: http:\/\/tabnet.datasus.gov.br\/cgi\/tabcgi.exe?sim\/cnv\/obt10uf.def [Last accessed: Nov7 2025]."},{"key":"e_1_3_3_3_1","unstructured":"2.World Health Organization (WHO). Global health estimates 2020: Deaths by cause age sex by country and by region 2000\u20132019. Geneva: WHO; 2020. Dispon\u00edvel em. Available from: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/the-top-10-causes-of-death [Last accessed: Nov7 2025]."},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000051705.97966.AD"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2013.491"},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.37275\/bsm.v8i4.976"},{"key":"e_1_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/07853890.2021.1925150"},{"key":"e_1_3_3_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2021.759333"},{"key":"e_1_3_3_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241713338"},{"key":"e_1_3_3_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/imcb.12409"},{"key":"e_1_3_3_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-018-4005-4"},{"key":"e_1_3_3_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-76838-0"},{"key":"e_1_3_3_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom11081144"},{"key":"e_1_3_3_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10071155"},{"key":"e_1_3_3_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10517-015-2928-3"},{"key":"e_1_3_3_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2020.10.258"},{"key":"e_1_3_3_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2021.111273"},{"key":"e_1_3_3_18_1","doi-asserted-by":"publisher","DOI":"10.1017\/jns.2016.41"},{"key":"e_1_3_3_19_1","doi-asserted-by":"publisher","DOI":"10.3109\/14756366.2015.1057723"},{"key":"e_1_3_3_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics9020045"},{"key":"e_1_3_3_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26175377"},{"issue":"4","key":"e_1_3_3_22_1","first-page":"104","article-title":"Model 5\/6 nefrektomie, jako experiment\u00e1ln\u00ed model chronick\u00e9 ren\u00e1ln\u00ed insuficience a adaptace ledvin na redukci poctu nefron\u016f [5\/6 nephrectomy as an experimental model of chronic renal failure and adaptation to reduced nephron number]","volume":"57","author":"Kujal P","year":"2008","unstructured":"21.Kujal P, , Vernerov\u00e1 Z. Model 5\/6 nefrektomie, jako experiment\u00e1ln\u00ed model chronick\u00e9 ren\u00e1ln\u00ed insuficience a adaptace ledvin na redukci poctu nefron\u016f [5\/6 nephrectomy as an experimental model of chronic renal failure and adaptation to reduced nephron number]. 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