{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:07:42Z","timestamp":1788998862054,"version":"build-2803163510"},"reference-count":57,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medicinal Food"],"published-print":{"date-parts":[[2026,10,1]]},"abstract":"<jats:p>\n                    Obesity and mental health disorders are among the greatest public health challenges of the 21st century. Interestingly, an altered microbiome profile has been associated with both conditions. The aim of this randomized, double-blind, placebo-controlled clinical trial was to evaluate the effects of dietary supplementation with a specific probiotic strain (\n                    <jats:italic toggle=\"yes\">Lactiplantibacillus plantarum<\/jats:italic>\n                    KABP051) on body composition and gut microbiome balance, together with measures of mood state, in a population of healthy overweight subjects. Sixty healthy, moderately stressed, nondepressed and overweight or obese volunteers were supplemented for 12 weeks with probiotic (\n                    <jats:italic toggle=\"yes\">L. plantarum<\/jats:italic>\n                    KABP051; 1 billion colony forming units\/day) or placebo (microcrystalline cellulose). The KABP051 group experienced significantly greater improvements compared with placebo on body composition measurements, including a reduction in body weight and waist circumference, which decreased in 1.97 \u00b1 0.77 (mean \u00b1 SE) kg and 2.15 \u00b1 0.81 (mean \u00b1 SE) cm versus placebo at the end of the intervention (both\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; .05, mixed model for repeated measures [MMRM] and\n                    <jats:italic toggle=\"yes\">post-hoc<\/jats:italic>\n                    analysis). Microbiome composition improved in KABP051 group, with significant increase in the relative abundance of\n                    <jats:italic toggle=\"yes\">Lactiplantibacillus<\/jats:italic>\n                    spp. versus placebo. Body fat percentage, profile of mood states fatigue, and confusion sub-scores showed a global trend toward improvement compared with placebo, with the change at 12 weeks being significant in the three measurements in\n                    <jats:italic toggle=\"yes\">post-hoc<\/jats:italic>\n                    analysis (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = .015,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = .014, and\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = .016, respectively). No serious adverse events were registered during the intervention period. These results suggest that a specific strain of probiotic bacteria (\n                    <jats:italic toggle=\"yes\">L. plantarum<\/jats:italic>\n                    KABP051) may have both metabolic and psychobiotic effects and may be beneficial for enhancing weight loss and body composition, improving energy (less fatigue) and mood levels while embarking on a healthy lifestyle regimen. ClinicalTrials.gov identifier: NCT06808061.\n                  <\/jats:p>","DOI":"10.1177\/1096620x261448041","type":"journal-article","created":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T07:44:30Z","timestamp":1777707870000},"page":"603-610","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of\n                    <i>Lactiplantibacillus plantarum<\/i>\n                    KABP051 Probiotic on Body Composition, Microbiome and Mood in Healthy Overweight Adults"],"prefix":"10.1177","volume":"29","author":[{"given":"Shawn","family":"Talbott","sequence":"first","affiliation":[{"name":"3 Waves Wellness, Plymouth, Massachusetts, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bret","family":"Stephens","sequence":"additional","affiliation":[{"name":"Wasatch Scientific, Murray, Utah, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Talbott","sequence":"additional","affiliation":[{"name":"3 Waves Wellness, Plymouth, Massachusetts, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Oddou","sequence":"additional","affiliation":[{"name":"Wasatch Scientific, Murray, Utah, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aoki","family":"Fumiki","sequence":"additional","affiliation":[{"name":"Kaneka Americas Holdings Inc., Pasadena, Texas, USA."},{"name":"AB-Biotics S.A., Barcelona, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,5,1]]},"reference":[{"key":"e_1_3_3_2_1","unstructured":"1.World Health Organization (WHO). 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