{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,14]],"date-time":"2026-11-14T10:22:05Z","timestamp":1794651725990,"version":"4.9.1"},"reference-count":22,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T00:00:00Z","timestamp":1789344000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Japan Society for the Promotion of Science","award":["KAKENHI (21H02149 and 24K01712)"],"award-info":[{"award-number":["KAKENHI (21H02149 and 24K01712)"]}],"id":[{"id":"https:\/\/ror.org\/00hhkn466","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medicinal Food"],"published-print":{"date-parts":[[2026,12,1]]},"abstract":"<jats:p>Bee larvae (BL) have a long history of use as both traditional medicine and food. Given that BL contain anti-inflammatory lipids and immune-modulating components, they may be efficacious against hearing loss and tinnitus. In this study, we investigated the effects of enzymatically processed BL on the suppression of hearing loss using mouse models of acute acoustic injury and noise-induced hearing loss (NIHL). In an assay where C57BL\/6 mice were exposed to a single 5-min burst of 110 dB white noise, pre-treatment with BL was found to reduce transient acoustic damage. Furthermore, under conditions of repeated 10-min noise exposures to induce NIHL, consumption of enzymatically processed BL mitigated the progression of hearing impairment. Additionally, antioxidant activity was confirmed in the enzymatically processed BL. Cellular assays and analysis of hexane extract fractions suggested that BL reduces noise-induced oxidative stress in the inner ear. Collectively, these findings demonstrate that enzymatically processed BL exert protective effects against the progression of hearing loss.<\/jats:p>","DOI":"10.1177\/1096620x261481445","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T05:08:21Z","timestamp":1789448901000},"page":"756-761","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Dietary Intake of Enzymatically Processed Bee Larvae Mitigates Progressive Noise-Induced Hearing Impairment in Mice"],"prefix":"10.1177","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6139-5726","authenticated-orcid":false,"given":"Hideaki","family":"Oike","sequence":"first","affiliation":[{"name":"Institute of Livestock and Grassland Science, National Agriculture and Food Research Organization (NARO), Tsukuba, Ibaraki, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuaki","family":"Okumura","sequence":"additional","affiliation":[{"name":"Institute for Bee Products and Health Science, Yamada Bee Company Inc., Tomata-gun, Okayama, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Kawabe","sequence":"additional","affiliation":[{"name":"Institute for Bee Products and Health Science, Yamada Bee Company Inc., Tomata-gun, Okayama, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,9,14]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.3736\/jintegrmed2013051"},{"issue":"6","key":"e_1_3_3_3_1","first-page":"1013","article-title":"Beneficial effect of protease-digested bee lavae on aging male\u2019s symptoms, erectile function and related health conditions","volume":"48","author":"Ito T","year":"2020","unstructured":"2.Ito T, , Nobuaki O, , Ayanori Y, et al. Beneficial effect of protease-digested bee lavae on aging male\u2019s symptoms, erectile function and related health conditions. JPN Pharmacol Ther 2020;48(6):1013\u20131023.","journal-title":"JPN Pharmacol Ther"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/03670240500187278"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.5851\/kosfa.2019.e53"},{"key":"e_1_3_3_6_1","unstructured":"5.WHO. Deafness and hearing loss. 2025. Available from: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/deafness-and-hearing-loss"},{"key":"e_1_3_3_7_1","volume-title":"World report on hearing","author":"WHO","year":"2021","unstructured":"6.WHO. World report on hearing. World Health Organization: 2021."},{"key":"e_1_3_3_8_1","doi-asserted-by":"publisher","DOI":"10.14336\/ad.2017.0930"},{"key":"e_1_3_3_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/mao.0000000000001700"},{"key":"e_1_3_3_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/bbb\/zbac092"},{"key":"e_1_3_3_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep23556"},{"key":"e_1_3_3_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12051416"},{"key":"e_1_3_3_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2021.111335"},{"key":"e_1_3_3_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0322105"},{"key":"e_1_3_3_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/AUD.0b013e318234f024"},{"key":"e_1_3_3_16_1","doi-asserted-by":"publisher","DOI":"10.35702\/Trad.10011"},{"issue":"4","key":"e_1_3_3_17_1","first-page":"507","article-title":"Significant symptomatic benefit of the enzymolyzed honeybee larvae for patients with Mild Self\u2014perceived Tinnitus Handicap\u2015A Double\u2014blind Placebo\u2014controlled Trial","volume":"43","author":"Aoki M","year":"2015","unstructured":"16.Aoki M. Significant symptomatic benefit of the enzymolyzed honeybee larvae for patients with Mild Self\u2014perceived Tinnitus Handicap\u2015A Double\u2014blind Placebo\u2014controlled Trial. \u2015Jpn Pharmacol Ther 2015;43(4):507\u2013514.","journal-title":"Jpn Pharmacol Ther"},{"issue":"4","key":"e_1_3_3_18_1","first-page":"627","article-title":"Beneficial effect of enzymolyzed honeybee larvae powder on tinnitus symptoms\u2014A randomized, single-blind, placebo-controlled, parallel-group comparison study","volume":"46","author":"Ohkuma A","year":"2018","unstructured":"17.Ohkuma A, , Nagae H, , Kawaguchi M. Beneficial effect of enzymolyzed honeybee larvae powder on tinnitus symptoms\u2014A randomized, single-blind, placebo-controlled, parallel-group comparison study. Japanese Pharmacol Ther 2018;46(4):627\u2013637.","journal-title":"Japanese Pharmacol Ther"},{"key":"e_1_3_3_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/foods12224058"},{"key":"e_1_3_3_20_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.b21-00239"},{"key":"e_1_3_3_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10121880"},{"key":"e_1_3_3_22_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2845-09.2009"},{"issue":"2","key":"e_1_3_3_23_1","first-page":"70","article-title":"Protective effects of N-acetylcysteine on noise-induced hearing loss in guinea pigs","volume":"29","author":"Fetoni AR","year":"2009","unstructured":"22.Fetoni AR, , Ralli M, , Sergi B, et al. Protective effects of N-acetylcysteine on noise-induced hearing loss in guinea pigs. Acta Otorhinolaryngol Ital 2009;29(2):70\u201375; doi: 20111615","journal-title":"Acta Otorhinolaryngol Ital"}],"container-title":["Journal of Medicinal Food"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1096620X261481445","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1096620X261481445","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1096620X261481445","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,11,14]],"date-time":"2026-11-14T09:46:22Z","timestamp":1794649582000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1096620X261481445"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,14]]},"references-count":22,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2026,12,1]]}},"alternative-id":["10.1177\/1096620X261481445"],"URL":"https:\/\/doi.org\/10.1177\/1096620x261481445","relation":{},"ISSN":["1096-620X","1557-7600"],"issn-type":[{"value":"1096-620X","type":"print"},{"value":"1557-7600","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,14]]}}}