{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T19:51:23Z","timestamp":1791402683471,"version":"4.3.3"},"reference-count":47,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T00:00:00Z","timestamp":1788134400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medicinal Food"],"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      <jats:italic toggle=\"yes\">Helicobacter pylori<\/jats:italic>\n                      remains a major cause of chronic gastritis and dyspeptic symptoms, and the effectiveness of standard eradication therapy continues to decline with increasing antibiotic resistance.\n                      <jats:italic toggle=\"yes\">Lacticaseibacillus paracasei<\/jats:italic>\n                      HP7 has shown inhibitory and anti-inflammatory effects on\n                      <jats:italic toggle=\"yes\">H. pylori<\/jats:italic>\n                      in preclinical studies. This study investigated whether 8-week oral HP7 supplementation could improve\n                      <jats:italic toggle=\"yes\">H. pylori<\/jats:italic>\n                      -related outcomes in adults with confirmed infection. Seventy-eight adults with positive\n                      <jats:sup>13<\/jats:sup>\n                      C-urea breath test (\n                      <jats:sup>13<\/jats:sup>\n                      C-UBT) results and gastric discomfort were randomized to receive low-dose HP7 (HP7-L, 1.5 \u00d7 10\n                      <jats:sup>9<\/jats:sup>\n                      CFU\/day), high-dose HP7 (HP7-H, 5.0 \u00d7 10\n                      <jats:sup>9<\/jats:sup>\n                      CFU\/day), or placebo for 8 weeks. Outcomes included changes in\n                      <jats:sup>13<\/jats:sup>\n                      C-UBT values, upper gastrointestinal (GI) symptoms assessed by Korean Gastrointestinal Symptom Rating Scale, pepsinogen I\/II ratio, serum tumor necrosis factor-\u03b1, and quality-of-life indices. HP7-H significantly reduced\n                      <jats:sup>13<\/jats:sup>\n                      C-UBT values compared with placebo. HP7 supplementation was also associated with improvements in gastric mucosal biomarkers and modest changes in selected upper GI symptom and quality-of-life domains. Overall microbial diversity was not significantly altered, although the abundance of\n                      <jats:italic toggle=\"yes\">L. paracasei<\/jats:italic>\n                      increased following supplementation. No treatment-related serious adverse events were observed, and all laboratory findings remained within clinical reference ranges. Complete eradication of\n                      <jats:italic toggle=\"yes\">H. pylori<\/jats:italic>\n                      was not achieved in most participants. These findings support the clinical potential of HP7 supplementation to attenuate\n                      <jats:italic toggle=\"yes\">H. pylori<\/jats:italic>\n                      -related activity and improve gastric biomarkers, with modest benefits in selected dyspeptic symptom domains. HP7 may be a safe and effective functional food option for\n                      <jats:italic toggle=\"yes\">H. pylori<\/jats:italic>\n                      management when antibiotics are contraindicated or ineffective. Further studies are warranted to confirm long-term efficacy and durability of these effects.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1096620x261481599","type":"journal-article","created":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T11:14:01Z","timestamp":1788174841000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["<i>Lacticaseibacillus paracasei<\/i>\n                    HP7 Attenuates\n                    <i>Helicobacter pylori<\/i>\n                    Activity and Improves Upper Gastrointestinal Symptoms: A Double-Blind, Randomized, Placebo-Controlled, Clinical Trial"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0581-8592","authenticated-orcid":false,"given":"Jae-Ho","family":"Lee","sequence":"first","affiliation":[{"name":"R&amp;BD Center, hy Co., Ltd, Yongin-si, South 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Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong-Cheon","family":"Joo","sequence":"additional","affiliation":[{"name":"Department of Sasang Constitutional Medicine, College of Korean Medicine, Wonkwang University, eollabuk-do, South Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae-Hwan","family":"Lee","sequence":"additional","affiliation":[{"name":"R&amp;BD Center, hy Co., Ltd, Yongin-si, South 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